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The aim of the project is to elucidate the impact of diverse sex hormone profiles on the adaptability of muscle mass to physical training. Additionally, the project aims to investigate secondary effects on adipose tissue, tendons, and other physiological parameters associated with physical function.
The human study is designed as a prospective study where 3 groups with different sex hormonal profiles are followed in parallel in 4 months and tested before, during (2 months) and after 4 months of physical training intervention. The three groups include a control group with regular menstrual bleeding and two groups who have an altered sex hormonal profile due to use of either IUD (containing the progestin levonorgestrel) or mini pills (containing the progestin desogestrel). Before and after the training period the following will be measured/collected: Body composition, Dietary intake, Physical Activity Level, Blood, Urine, Muscle Tissue, Adipose Tissue, Aerobic capacity in bike test, Strength and muscle function tests, and questionnaires about diet and physical activity.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Non-hormonal contraception users | Active Comparator | Non-hormonal contraception users |
|
| IUD users | Experimental | IUD users |
|
| Progestin only pill users | Experimental | Progestin only pill users |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Physical training | Behavioral | Aerobic and resistance training three times per week. Two supervised training sessions. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Muscle mass | Muscle mass measured by DXA | 4 months |
| Fat free mass | Fat free mass measured by DXA | 4 months |
| Measure | Description | Time Frame |
|---|---|---|
| Muscle fiber type measured by histochemical staining | Muscle fiber type measured by histochemical staining | 4 months |
| Protein expression in skeletal muscle tissue | Expression of Muscle protein signaling markers for muscle protein degradation and synthesis pathways |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mette Hansen, PhD | Contact | +4551666551 | mhan@ph.au.dk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Aarhus University, Department for Public Health | Recruiting | Aarhus | Jutland | 8000 | Denmark |
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| ID | Term |
|---|---|
| D064797 | Physical Conditioning, Human |
| ID | Term |
|---|---|
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
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| 4 months |
| Adipose tissue sex hormone receptors | Adipose tissue sex hormone receptors | 4 months |
| Resting metabolic rate | Resting metabolic rate measured via indirect calorimetry | 4 months |
| Maximal oxygen uptake | Maximal oxygen uptake | 4 months |
| Muscle strength | Muscle strength (arm and finger strength) | 4 months |
| Appetite regulatory markers | Leptin, Ghrelin, CCK, GLP-1 | 4 months |
| Lipid profile | Lipid profile | 4 months |
| Muscle fiber cross sectional area | Muscle fiber cross sectional area measured by histochemical stainings | 4 months |
| D055687 |
| Musculoskeletal and Neural Physiological Phenomena |