The aim of this study is to compare bovine bone with or without concentrated growth factor in the treatment of chronic periodontitis.

Periodontitis is an infection-driven inflammatory disease resulting from dental plaque accumulation at the gingival margin, triggering an inflammatory response that leads to microbial alterations and may have severe consequences for the periodontium of susceptible individuals.

The xenograft most commonly used in periodontal regeneration procedures is the deproteinized bovine or equine bone mineral.

Platelets are known to play a significant role in guided tissue regeneration (GTR) by releasing several growth factors, such as platelet-derived growth factor (PDGF), and plasma rich in growth factors (PRGF), which are present in platelet-rich plasma (PRP), a first-generation platelet concentrate. Platelet-rich fibrin (PRF) and concentrated growth factors (CGF) are considered the second generation of platelet concentrate.

Inclusion Criteria:

• Presence of angular periodontal intra-bony defects with a pocket depth (PD) ≥ 5mm.
• Optimal compliance as evidenced by no missed treatment appointments and a positive attitude towards oral hygiene.
• Full-mouth bleeding score ≤ 25%.

Exclusion Criteria:

• Patients with relevant medical conditions that may affect periodontal regeneration and periodontal surgery.
• Patients who have any disease or take any medication that affects the normal number or function of platelets.
• Smokers.
• Pregnant or lactating women.
• Patients in whom periodontal surgery had previously been carried out on the selected site.
• Patients with aggressive periodontitis.

The data will be available upon a reasonable request from the corresponding author after the end of study for one year.

After the end of study for one year.

The data will be available upon a reasonable request from the corresponding author.