Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen

Treatment of Periodontal Intra-bony Defects With a Volume Stable Collagen Matrix or Deproteinized Bovine Bone Mineral With 10% Collagen. A 12-month Multi-center Randomized Controlled Trial

To compare the healing of intrabony periodontal defects treated with either open flap debridement and a volume-stable collagen matrix (VCMX) or a deproteinized bovine bone mineral with 10% collagen. The results will shed light on the clinical potential of VCMX in regenerative periodontal surgery and help to develop new treatment strategies.

Inclusion Criteria

• Patients with localized or generalized periodontitis Stage III and Stage IV, Grade A-B-C
• Males and females
• Age at least 18 years and older
• Presence of interdental intra-bony defects (I, II and III walls) in either the maxilla or the mandible with a PD ≥ 6 mm
• Defects with an intra-bony component > 3 mm for both groups
• Intra-bony defect located only at one aspect (mesial or distal)
• Presence of at least 2 mm of keratinized soft tissue. Exclusion Criteria
• Patients with systemic disease that could interfere with periodontal wound healing
• Prolonged antibiotic treatment or anti-inflammatory treatment within 4 weeks prior to surgery
• Pregnant or lactating
• Smokers with > 10 cig./day
• Patients with FMPS and FMBS > 25 % after completion of non-surgical periodontal therapy
• Multi-rooted teeth with furcation involvement
• Third molars
• Teeth with circumferential defects
• Interdental craters
• Written Informed Consent