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A comparison between precedex versus solumedrol as anti-inflammatory stress response inhibitors in patients undergoing on-pump CABG using different inflammatroy response parameters and the outcome of the drugs on the cognitive and cardiac status post extubation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control | Active Comparator | Control group receiving 10 ml of normal saline after induction of anesthesia then followed by infusion of normal saline till extubation in ICU |
|
| Dexmedetomidine | Active Comparator | Starting with precedex loading dose after anesthesia induction then infusion till extubation in ICU |
|
| Methylprednisolone | Active Comparator | To be diluted in 10 ml normal saline then given after induction of anesthesia then followed by normal saline infusion till extubation in ICU |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Normal saline | Drug | After induction of anesthesia give 10 ml of normal saline then followed by infusion of normal saline till extubation of patient in ICU |
|
| Measure | Description | Time Frame |
|---|---|---|
| Induced inflammatory response | Effect of both drugs on attenuating induced inflammatory response | First 24 hours post cardio-pulmonary bypass |
| Measure | Description | Time Frame |
|---|---|---|
| Cognitive function | Assesment of post operative cognitive function and occurnce of post operative delerium using CAM-ICU score | First 24 hours post cardio-pulmonary bypass |
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Inclusion Criteria:
Exclusion Criteria:
9.Infection during the week preceding surgery white blood cell count over 11,000 mm3 10.Pre-operative use of antibiotics or corticosteroids.
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Assem Abourawash, Masters | Contact | 00201064013278 | assemahmed999@gmail.com |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | Cairo Governorate | Egypt |
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Control group without any medications Dexmedetomidine group Methylprednisolone group
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Randomized Double blinded clinical trial
| Dexmedetomidine | Drug | After induction of anesthesia give loading dose of precedex 1 mcg/kg diluted in 10 ml normal saline then attach syringe pump of precedex infusion of 0.5mcg/kg/hr till extubation in ICU |
|
|
| Methylprednisolone | Drug | After induction of anesthesia give solumedrol of a dose 10mg/kg diluted in 10ml of normal saline followed by a normal saline infusion till the extubation of the patient in the ICU |
|
|
| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| D018746 | Systemic Inflammatory Response Syndrome |
| D011183 | Postoperative Complications |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
| D001161 | Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
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| ID | Term |
|---|---|
| D000077330 | Saline Solution |
| D035061 | Control Groups |
| D020927 | Dexmedetomidine |
| D008775 | Methylprednisolone |
| D008776 | Methylprednisolone Hemisuccinate |
| ID | Term |
|---|---|
| D000077324 | Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D015340 | Epidemiologic Research Design |
| D004812 | Epidemiologic Methods |
| D008919 | Investigative Techniques |
| D012107 | Research Design |
| D008722 | Methods |
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
| D011239 | Prednisolone |
| D011246 | Pregnadienetriols |
| D011245 | Pregnadienes |
| D011278 | Pregnanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
| D011083 | Polycyclic Compounds |
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