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50 patients of both sexes undergoing elective CABG surgery will be randomly divided into 2 groups, study group (Dex) group and control group (C) to determine the effect of dexmedetomidine on the peri-operative hemodynamic changes during CABG surgery.
The effect of dexmedetomidine during CABG surgery is studied regarding Ventricular function, pre bypass and post bypass using the transoeophageal echo (TEE), post-operative by transthoracic echocardiography (TTE) on day of surgery and after extubation.
Incidence of intraoperative and post operative ischemia and arrhythmias using Electrocardiogram (ECG) as well as the length of ICU and hospital stay.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Dexmedetomidine group | Active Comparator | patients will have loading Dexmedetomidine( 1ug/kg) over 10 minutes followed by continuous infusion of (0.5ug/kg/hr) from the initiation of anaesthesia up to extubation in the ICU. Patients will not be extubated until completely awake and have no sign of arrhythmias and bleeding |
|
| control group | Placebo Comparator | patients will receive the same volume of 0.9% saline infusion as loading and maintenance infusion. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Dexmedetomidine | Drug | a central sympatholytic drug |
|
| Measure | Description | Time Frame |
|---|---|---|
| Intra-operative ventricular function. | global systolic function Ejection Fraction by TEE intraoperative | Intraoperative |
| post-operative ventricular function. | global systolic function Ejection Fraction by TTE postoperative | Up to 24 hours postoperative |
| Measure | Description | Time Frame |
|---|---|---|
| hemodynamics | Heart Rate (beat/minute), | Immediate postoperative and up to 24 hours postoperative |
| hemodynamics | Mean arterial blood pressure (mmHg) |
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Inclusion Criteria:
Exclusion Criteria:
Patient refusal
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | Abassia | Egypt |
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| ID | Term |
|---|---|
| D020927 | Dexmedetomidine |
| D000077330 | Saline Solution |
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D007093 | Imidazoles |
| D001393 | Azoles |
| D006573 | Heterocyclic Compounds, 1-Ring |
| D006571 | Heterocyclic Compounds |
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| normal saline | Other | saline is given to control group |
|
|
| Immediate postoperative and up to 24 hours postoperative |
| D000077324 |
| Crystalloid Solutions |
| D007552 | Isotonic Solutions |
| D012996 | Solutions |
| D004364 | Pharmaceutical Preparations |
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
| D017670 | Sodium Compounds |