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The study aimed at filling the gaps by evaluating the effectiveness of vitamin-D as an adjuvant to phototherapy in reduction of indirect serum bilirubin among neonates with exaggerated physiological hyperbilirubinemia.
If vitamin-D has been found effective as an adjuvant to phototherapy in the treatment of exaggerated physiological hyperbilirubinemia, it may help to reduce the serum bilirubin level rapidly. It may also reduce the complications by shortening the duration of phototherapy to offer better patient compliance and better patient outcomes.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Vitamin D3 group | Experimental | Neonates were given vitamin D3 (cholecalciferol) in an oral drops formulation (400 IU/drop), at a dose of 400 IU once a day for 72 hours as an adjuvant therapy to phototherapy. |
|
| Phototherapy group | Experimental | Neonates received only phototherapy for 72 hours. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Vitamin D3 | Drug | Neonates were given vitamin D3 (cholecalciferol) in an oral drops formulation (400 IU/drop), at a dose of 400 IU once a day until the serum bilirubin level was out of phototherapy range or a maximum of 72 hours as an adjuvant therapy to phototherapy. |
| Measure | Description | Time Frame |
|---|---|---|
| Bilirubin reduction comparison | Net reductions in bilirubin levels in two groups after 72 hours were compared. | 72 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Hafsah Naz | Mayo Hospital, Lahore, Pakistan | Principal Investigator |
| Muhammad Ashfaq | Mayo Hospital, Lahore, Pakistan | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Mayo Hospital | Lahore | Punjab Province | 54000 | Pakistan |
The data can be shared on a reasonable request.
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| ID | Term |
|---|---|
| D006932 | Hyperbilirubinemia |
| ID | Term |
|---|---|
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D002762 | Cholecalciferol |
| D010789 | Phototherapy |
| ID | Term |
|---|---|
| D002782 | Cholestenes |
| D002776 | Cholestanes |
| D013256 | Steroids |
| D000072473 | Fused-Ring Compounds |
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| Phototherapy | Procedure | Neonates received only phototherapy until the serum bilirubin level was out of phototherapy range or a maximum of 72 hours. |
|
| D011083 |
| Polycyclic Compounds |
| D013261 | Sterols |
| D014807 | Vitamin D |
| D012632 | Secosteroids |
| D008563 | Membrane Lipids |
| D008055 | Lipids |
| D013812 | Therapeutics |