Patient undergoing surgeries in general anesthesia require support of their breathing by ventilator. Different strategies can be used to manage breathing of the patient. Lung protective ventilation provides breathing at a set volume determined by patient ideal body weight, along with a set rate to maintain adequate breathing. The pressures in the lower airway are kept less than 30 cm of H20 while a pressure of 5cm of H20 is applied to prevent lung collapse. Recently to above mentioned regimen a driving pressure is added which is a difference between lower airway pressure and pressure applied to prevent lung collapse. Ventilatory settings are adjusted to keep this driving pressure less than 15 cm of H2O.

Lung protective ventilation provides tidal volume at 6-8 ml/kg along with a set respiratory while keeping plateau pressure less than 30cm of H2O and Peak pressure less than 35cm of H2O and PEEP of 5cm of H20 is applied. The aim is to prevent volutrauma, barotrauma and atelectrauma. To above mentioned regimen another parameter is added that is driving pressure. It is manipulated by adjusting PEEP level so that difference between Plateau Pressure and PEEP is less than equal to 15cm of water.

Inclusion Criteria:

• American Society of Anesthesiologists (ASA) class: I and II.
• Elective laparoscopic surgeries requiring General Anesthesia and Mechanical ventilation
• Patients receiving neuromuscular blockade during surgery.
• Receiving Mechanical ventilation for at least 1h.

Exclusion Criteria:

• Pregnancy
• Patients who had received mechanical ventilation of more than 1h in the previous 2 weeks.
• Body mass index >35 kg/m2
• Smokers and ASA class III and above.
• Thoracic and Cardiac surgery