Novel Biomarkers and Postoperative Kidney Injury in Radical Nephrectomy

Novel Biomarkers to Predict Acute Kidney Injury and Chronic Kidney Disease After Radical Nephrectomy: an Exploratory Prospective Cohort Study

The incidence of acute kidney injury (AKI) after radical nephrectomy exceeds 40%. Currently, the KDIGO criteria are the recognized diagnostic standard for AKI. These criteria primarily use serum creatinine and urine output as key indicators, but both parameters have certain limitations, such as delayed response, insensitivity, and inaccuracy. This study aims to simultaneously monitor perioperative novel renal damaging, stressful, and functional biomarkers in patients undergoing radical nephrectomy, and to investigate their predictive value for AKI and postoperative 1-year chronic kidney disease (CKD).

Inclusion Criteria:

• Age ≥18 years;
• Scheduled to undergo unilateral radical nephrectomy.

Exclusion Criteria:

• Solitary kidney;
• Preoperative diagnosis of chronic kidney disease stages G4 or G5 (GFR <30 mL/min/1.73m²);
• Tumor invasion of the vena cava requiring thrombectomy;
• Other conditions deemed by the investigator as unsuitable for participation in this study.