Biomarkers of Acute Kidney Injury in Cardiac Surgery

Biomarkers in Estimation for Risk of Acute Kidney Injury in Cardiac Surgery

Acute kidney injury (AKI) is the most common complication in patients after cardiac surgery. An usual estimation of risk for AKI is estimation of serum creatinine, which is unreliable indicator of AKI risk. Because of that, today different biomarkers are investigated to predict incidence for development AKI after cardiac surgery. This investigation will try to find potentially risk patients for developing AKI after cardiac surgery by using conventional markers (creatinine, glomerular filtration rate) in perioperative period comparing with two different biomarkers neutrophil gelatinase-associated lipocalin (NGAL) and growth differentiation factor 15 (GDF-15) which are proven markers in patients with increased risk for AKI development.

Inclusion Criteria:

• patients scheduled for cardiac surgery (CABG, valve replacement/repair, combined)
• older than 18 years

Exclusion Criteria:

• previous known renal disease
• patients on chronic dialysis