Colorectal cancer (CRC) often metastasizes to the liver, with synchronous metastases observed in 20% of cases. Surgical resection is the primary treatment, but the impact of simultaneous and staged resections on clinical outcomes remains unclear. This study employs propensity score matching (PSM) in a nationwide survey to compare clinical characteristics, complications, and survival, providing valuable insights for optimizing the management of colorectal liver metastases.

Inclusion Criteria:

1) a histologically confirmed diagnosis of colorectal cancer with liver metastases; and 2) age ≥ 18 years

Exclusion Criteria:

1) extrahepatic metastases; and 2) ineligibility for curative surgical resection based on preoperative assessment.

This nationwide multicenter retrospective cohort study enrolled colorectal cancer patients with simultaneous liver metastases treated at 18 tertiary hospitals in China between January 2019 and December 2021.