Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Pregnant Women Undergoing Cesarean Section

Effect of Preoperative Prophylactic Intravenous Tranexamic Acid on Perioperative Blood Loss in Pregnant Women Undergoing Cesarean Section : A Randomized Controlled Trial

The purpose of this study is to asses the effect of preoperative prophylactic intravenous tranexamic acid on perioperative blood loss in pregnant women undergoing cesarean section

Inclusion Criteria:

• pregnant women with gestational age 37-42 weeks
• undergoing cesarean delivery with indication as follows: placenta previa, severe preeclampsia, myoma uteri, fetal macrosomia, polyhydramnios, grand multiparity ≥ 5 deliveries, prolonged labor, etc.

Exclusion Criteria:

• history of allergy to tranexamic acid
• history of venous thromboembolism (Deep vein thrombosis, Pulmonary embolism)
• history of arterial thrombosis (Myocardial infarction, Stroke)
• history of seizure, convulsion
• have underlying of cardiovascular, renal or liver disease
• using of antiplatelet or anticoagulant within 1 week before operation
• placenta accreta spectrum
• abruptio placenta
• Eclampsia or HELLP (Hemolysis Elevated Liver Low Platelet) syndrome
• Failed operative vaginal delivery
• Multifetal gestation