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This study evaluate role of tranexamic acid in reducing blood loss among pregnant women undergoing cesarean section because of placenta previa .Half of participants will receive tranexamia acid drug While the other half will receive placebo.
Tranexamic Acid used in the field of obstetrics to decrease blood loss during and after cesarean section .
Tranexamic Acid is an antifibrinolytic agent which cause reversible and competitive blockade of the lysine binding sites in plasminogen molecules . It is a synthetic analog of amino acid lysine and its action is to reduce blood loss
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tranexamic acid group | Experimental | tranexamic acid given as 1 gram intravenous dose dilute in 500 cc of ringer lactate 20 minute before cesarean section |
|
| placebo group | Placebo Comparator | the control group will receive 500 cc of ringer lactate 20 minute before cesarean section |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Tranexamic Acid | Drug | tranexamic acid or placebo are given before cesarean section in patient with placenta previa |
|
| Measure | Description | Time Frame |
|---|---|---|
| Amount of Actual blood loss in each group | observational | 6hour after operation |
| Measure | Description | Time Frame |
|---|---|---|
| Difference in haemoglobin before operation and 24 hours after operation | observational | 24 hours |
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Inclusion Criteria:
Exclusion Criteria:
other causes ofantepartum haemorrhage eg :accidental haemorrhage, rupture uterus.
type 1,2 of placenta previa anterior type 3,4 of placenta previa posterior causes of overdistended uterus like :multiple pregnancy, polyhydraminos
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| ID | Term |
|---|---|
| D014148 | Tranexamic Acid |
| ID | Term |
|---|---|
| D003509 | Cyclohexanecarboxylic Acids |
| D000146 | Acids, Carbocyclic |
| D002264 | Carboxylic Acids |
| D009930 | Organic Chemicals |
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