Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
Patients undergoing hemodialysis (HD) frequently exhibit elevated serum uric acid (SUA) levels, which are associated with cardiovascular risks, joint issues, and diminished quality of life (QoL). Aerobic exercise has been shown to improve cardiovascular health and reduce SUA levels in various populations, suggesting potential benefits for HD patients.
Objective: This study aimed to investigate the impact of aerobic exercise on serum uric acid (SUA) levels, functional capacity, and quality of life (QoL) in patients undergoing hemodialysis (HD).
Methods: This randomized controlled trial will recruit 32 participants, aged 40-60, undergoing HD. The intervention group (Group A) will participate in a structured 6-week aerobic exercise program, while the control group (Group B) will receive only conventional physical therapy. Pre- and post-intervention assessments included SUA levels, the Six-Minute Walk Test (6MWT), and the Kidney Disease Quality of Life Short Form (KDQOL-SF™)
32 Subjects of both genders will participate in this study at El-khazendara Hospitals with age ranged between (40-60) years old. They will receive a comprehensive verbal and written explanation of the study, including its objectives, procedures, and potential benefits.
participants will randomly assigned into two equal groups using a sealed-envelope randomization method to ensure unbiased allocation.
Group A (study Group): 16 HD patients receiving a conventional physical therapy program (breathing, stretching, and lower limb circulatory exercises) plus the aerobic exercise program.
Group B (Control Group): 16 HD patients receiving only the conventional physical therapy program.
6-weeks of aerobic exercise program (3 sessions per week, 20-45 minutes each session)
Outcome measures include:
Not provided
Not provided
Not provided
Not provided
| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group A | Experimental | Group A (study Group): 16 HD patients received a conventional physical therapy program (breathing, stretching, and lower limb circulatory exercises) combined with the aerobic exercise program. |
|
| Group B | Active Comparator | Group B (Control Group): 16 HD patients received only the conventional physical therapy program. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Aerobic Exercises | Other |
Use moderate-intensity exercise, aiming for 60-70% of the p |
| Measure | Description | Time Frame |
|---|---|---|
| Serum Uric Acid | from enrollment to the end of 6 weeks of treatment |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Functional ability of the patient | Assessed by using the Six-Minute Walk Test (6MWT), a validated tool used to evaluate exercise tolerance and endurance in clinical populations. | from enrollment to the end of 6 weeks of treatment |
| Change in Quality of life |
Not provided
Inclusion Criteria:
Exclusion Criteria:
Not provided
Not provided
Not provided
Not provided
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Doaa Rafat Assistant professor of physical therapy - Cairo university | Contact | 201005591580 | doaa.rafat@pt.cu.edu.eg | |
| Mahetab Gamal Ali | Contact | 201009502621 | Mahetab.gamal@gmail.com |
| Name | Affiliation | Role |
|---|---|---|
| Heba Elfeky Lecturer of physical therapy - Cairo University, lecturer | Department of Basic sciences for physical therapy, Faculty of Physical Therapy , Cairo university, Cairo, Egypt | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Physical Therapy faculty, Cairo University | Recruiting | Cairo | Egypt |
Not provided
| ID | Term |
|---|---|
| D015444 | Exercise |
| ID | Term |
|---|---|
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
Not provided
Not provided
Not provided
Not provided
Not provided
Not provided
|
| Conventional Program | Other | 1. Breathing Exercises - Diaphragmatic Breathing: Instruct patients to place one hand on their chest and the other on their abdomen. They should inhale deeply through their nose, allowing the abdomen to rise, and then exhale slowly through their mouth. This breathing technique has been shown to reduce stress, improve respiratory efficiency, and enhance relaxation . For optimal benefits, patients should practice this for 5-10 minutes, 2-3 times a day. Stretching Exercises Hamstring Stretch: Instruct patients to sit with one leg extended straight out in front of them and the other leg bent. They should reach towards the toes of the extended leg while keeping their back straight. Hold the stretch for 20-30 seconds and repeat the stretch 2-3 times per leg. Lower Limb Circulatory Exercises Ankle Pumps: While lying down or seated, instruct patients to alternately point and flex their feet to stimulate circulation and improve lower leg mobility. Perform 20-30 pumps per foot, 2-3 times a day |
|
Kidney Disease Quality of Life Short Form (KDQOL-SF™): The KDQOL-SF™ is a key tool used to assess the quality of life in patients with chronic kidney disease, particularly those undergoing hemodialysis. This version of the questionnaire measures multiple domains, including physical functioning, emotional well-being, and social roles, with a focus on issues specific to kidney disease such as symptoms, work status, and patient satisfaction. The scores are transformed into a scale from 0 to 100, with higher scores indicating a better quality of life |
| from enrollment to the end of 6 weeks of treatment |