This study aims to investigate if an integrated approach combining Traditional Chinese and Western medicine can better treat knee osteoarthritis. The goal is to see if this combined therapy can more effectively reduce pain severity and frequency, leading to an improved quality of life for KOA patients. Additionally, the study will explore the underlying mechanisms of pain and anti-inflammation related to KOA.

Inclusion Criteria:

• Male or female aged above 18 years old
• Kellgren-lawrence grading scale ≥ II
• Numerical rating scale (NRS) ≥ 4

Exclusion Criteria:

• History of bone tumor
• Pregnancy
• History of bilateral knee replacement
• Active infection