The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation

The Effect of Dexmedetomidine on Agitation During Weaning From Mechanical Ventilation in Critically Ill Patients"

This study aims to evaluate the effect of dexmedetomidine on the level of agitation during the weaning process from mechanical ventilation in critically ill patients.

Inclusion Criteria:

• Adult ICU patients (≥18 years).
• On mechanical ventilation ≥24 hours.
• Clinically ready for weaning.
• Agitation score RASS ≥ +1 during spontaneous breathing trial.
• Intubation for at least 4 days: 2 weeks.

Exclusion Criteria:

• Known hypersensitivity to dexmedetomidine.
• Hemodynamic instability (HR < 50 bpm or MAP < 60 mmHg).
• Neurological impairment affecting level of consciousness.
• Pregnancy or lactation.