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Dexmedetomidine is a selective α -2 agonist widely used in anesthesia for its sympatholytic, sedative and analgesic effects . Favorable respiratory effects in animals , and in selected human patient groups have been reported when using this agent .we investigated the effects of different doses of dexmedetomidine infusion on oxygenation
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group A | Active Comparator | Dexmedetomidine (Precedex) loadings of 1 μg/kg than continuously at a rate of 0.2 μg/(kg/h) till the end of the operation . |
|
| group B | Active Comparator | Dexmedetomidine (Precedex) loadings of 0.5 μg/kg then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation . |
|
| group C | Active Comparator | Dexmedetomidine (Precedex) loadings of 0.25 μg/kg(group C) then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation . |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| GROUP Dexmedetomidine | Drug | Dexmedetomidine (Precedex) loadings of 1 μg/kg , then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation . |
|
| Measure | Description | Time Frame |
|---|---|---|
| Oxygenation by the end study | PaO2/Fraction of inspired oxygen | UP TO 6 HOURE |
| Measure | Description | Time Frame |
|---|---|---|
| Intraoperative dynamic lung compliance | tidal volume/ (peak airway pressure -PEEP) | up to 6 hours |
| Intraoperative static lung compliance | Tidal volume/ (plateau pressure - PEEP) |
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Inclusion Criteria:
Morbidly obese patients with restrictive lung disease ASA I AND II laparoscopic sleeve gastrectomy
Exclusion Criteria:
history of heart failure history of cardiac arrhythmias severe liver or kidney impairment. Patients with forced expiratory volume in 1 sec (FEV1)/ FVC < 70%
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Amr S Wahdan, MD | Contact | 00201001422499 | amrwahdan@kasralainy.edu.eg |
| Name | Affiliation | Role |
|---|---|---|
| Amr s wahdan, MD | Cairo university , Cairo, Egypt | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Cairo university | Cairo | 11562 | Egypt |
still working
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| GROUP B | Drug | Dexmedetomidine (Precedex) loadings of 0.5 μg/kg , then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation . |
|
| GROUP C | Drug | Dexmedetomidine (Precedex) loadings of 0.25 μg/kg, then continuously at a rate of 0.2 μg/(kg/h) till the end of the operation . |
|
| UP TO 6 HOURE |
| Physiological dead space | 1.14 (PaCO2-EtCO2)/ PaCO2-0.005 | UP TO 6HOURE |