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Virtual Reality-based multi-dimensional intervention for cognition and well-being will be provided to older adults, with AI-agents. The digital health intervention include physical activity, gamification, cognitive trainings. Cognition, like memory, spatial function, sleepiness and mental health will be studied as outcomes.
In order to study the cognitive function and well-beings, qualitative methods (like questionnaires, interviews, focus groups) and quantitative methods (like ppg, ecg, eyetracker, eeg) will be used to collect data for analysis.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| control | No Intervention | usual care | |
| VR-based intervention | Experimental | Provide VR-based multi-dimensional intervention |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| VR-based multi-dimensional intervention | Device | VR-based multi-dimensional intervention, including LLMs, AI-agents |
|
| Measure | Description | Time Frame |
|---|---|---|
| Spatial cognition | mental rotation task,higher score means stronger spatial ability | pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
| Spatial cognition | money road map test, higher score means stronger spatial ability | pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
| Spatial cognition | building memory test, higher score means stronger spatial ability | pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
| Spatial cognition | corsi, , higher score means stronger spatial ability | pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
| Spatial cognition | digit span, higher score means stronger spatial ability | pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
| Measure | Description | Time Frame |
|---|---|---|
| mental health | UCLA loneliness, higher score means more loneliness | pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
| mental health | Positive and Negative Affect Schedule , 2 subscare, one is for positive, higher score means more positive affects, one is for negative, higher score mean more negetive affects |
| Measure | Description | Time Frame |
|---|---|---|
| Sleepiness | Effects on sleepiness, measured by The Pittsburgh Sleep Quality Index (PSQI) | pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
Inclusion Criteria:
Exclusion Criteria:
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Personal identity and health metrics are restricted and confidentially saved.
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| ID | Term |
|---|---|
| D003704 | Dementia |
| D000077260 | Sleepiness |
| D000092862 | Psychological Well-Being |
| D000544 | Alzheimer Disease |
| ID | Term |
|---|---|
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D019965 | Neurocognitive Disorders |
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two groups, one is control (usual care), one is VR-based multi-dimensional intervention, including LLMs, AI-agent
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| pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
| mental health | The World Health Organization-Five Well-Being Index (WHO-5), higher score means better mental well-being | pre-intervention, after 4 weeks, 8 weeks, 12 weeks, 16 weeks, 3 months, 6 months, 1 year, 2 year, 3 year |
| D001523 | Mental Disorders |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D010549 | Personal Satisfaction |
| D001519 | Behavior |
| D024801 | Tauopathies |
| D019636 | Neurodegenerative Diseases |