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| Name | Class |
|---|---|
| Tanta University | OTHER |
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Our study specifically will address the value of modified triglyceride glucose indices versus left ventricular speckle tracking in prediction of severity of coronary artery disease assessed by Gensini score.
A cross sectional study that will be conducted in Cardiovascular Department of Tanta University in Egypt in the period from May to July 2025 . Two hundred patients diagnosed with coronary artery diseases were included in the study. Patients were considered to have confirmed coronary artery disease through angiographically proven CAD.
Provision of privacy:
Privacy of all data is guaranteed and there will be a code number for every patient and include all of his or her investigations.
Informed consent:
Informed written consent will be obtained from all patients after full explanation of benefits and risks of the study.
Methods: Study patients and procedures:
Selection criteria included any patient with chronic stable angina and proved coronary artery disease by coronary angiography Exclusion criteria included: Any patients with acute coronary syndrome, arrhythmias, previous Percutaneous coronary intervention (PCI) or Coronary Artery Bypass Graft (CABG) surgery
All the participants were subjected to following:
History taking for presence of risk factors of cardio vascular disease as age, sex, smoking, physical inactivity, diabetes and hypertension.
Physical examination including height, weight and waste circumference
Resing 12 leads ECG
Laboratory investigations:
6. Coronary angiography 7. Gensini score calculated by summation of the individual coronary segment scores.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| TyG-derived index. | Diagnostic Test | Derived indices included:
|
| |
| Left Ventricular Speckle Tracking | Diagnostic Test | Coronary Angiography and Gensini Scoring: All participants underwent standard diagnostic coronary angiography. CAD was categorized as one-, two-, or three-vessel disease based on the number of vessels with ≥50% stenosis. The severity of CAD was quantified using the Gensini score, which assigns a severity weight to each lesion depending on degree of stenosis and anatomical location. Final scores were calculated by summing weighted values across all coronary segments. |
|
| Measure | Description | Time Frame |
|---|---|---|
| triglyceride-glucose (TyG) index | predictive value of the triglyceride-glucose (TyG) index and its modified forms (TyG×BMI, TyG×WC, TyG, ×, W,Ht,R ) with global longitudinal strain (GLS) in assessing coronary artery disease (CAD) severity, as quantified by the Gensini score. | 2 months |
| longitudinal strain (GLS) | Echocardiography parameter in assessing coronary artery disease (CAD) severity | 2 months |
| Gensini score. | Score assessing coronary artery disease (CAD) severity | 2 months |
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Inclusion Criteria:
Exclusion Criteria:
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Two hundred adult patients with chronic stable angina and angiographically confirmed coronary artery disease (CAD) were enrolled.
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| Name | Affiliation | Role |
|---|---|---|
| Eman Elshaikh, Ass. Prof. | Tanta University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Rehab Hussein Werida | Damanhūr | Elbehairah | 31527 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39560964 | Background | Siverio-Morales O, Mora-Fernandez C, Hernandez-Carballo C, Martin-Nunez E, Gonzalez-Luis A, Martin-Olivera A, Navarro-Gonzalez JF, Donate-Correa J. Predictive value of triglyceride-glucose index for the evaluation of coronary artery disease severity and occurrence of major adverse cardiovascular events. Am J Physiol Heart Circ Physiol. 2025 Jan 1;328(1):H14-H20. doi: 10.1152/ajpheart.00684.2024. Epub 2024 Nov 19. | |
| 36521498 |
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| ID | Term |
|---|---|
| D003324 | Coronary Artery Disease |
| ID | Term |
|---|---|
| D003327 | Coronary Disease |
| D017202 | Myocardial Ischemia |
| D006331 | Heart Diseases |
| D002318 | Cardiovascular Diseases |
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| Background |
| Lopez-Jaramillo P, Gomez-Arbelaez D, Martinez-Bello D, Abat MEM, Alhabib KF, Avezum A, Barbarash O, Chifamba J, Diaz ML, Gulec S, Ismail N, Iqbal R, Kelishadi R, Khatib R, Lanas F, Levitt NS, Li Y, Mohan V, Mony PK, Poirier P, Rosengren A, Soman B, Wang C, Wang Y, Yeates K, Yusuf R, Yusufali A, Zatonska K, Rangarajan S, Yusuf S. Association of the triglyceride glucose index as a measure of insulin resistance with mortality and cardiovascular disease in populations from five continents (PURE study): a prospective cohort study. Lancet Healthy Longev. 2023 Jan;4(1):e23-e33. doi: 10.1016/S2666-7568(22)00247-1. Epub 2022 Dec 12. |
| 31345238 | Background | Zhao S, Yu S, Chi C, Fan X, Tang J, Ji H, Teliewubai J, Zhang Y, Xu Y. Association between macro- and microvascular damage and the triglyceride glucose index in community-dwelling elderly individuals: the Northern Shanghai Study. Cardiovasc Diabetol. 2019 Jul 25;18(1):95. doi: 10.1186/s12933-019-0898-x. |
| D001161 |
| Arteriosclerosis |
| D001157 | Arterial Occlusive Diseases |
| D014652 | Vascular Diseases |