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| ID | Type | Description | Link |
|---|---|---|---|
| 5P20GM103440 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of General Medical Sciences (NIGMS) | NIH |
| University of Nevada, Reno | OTHER |
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The goal of this study is to better understand how stress impacts people's ability to learn across their experiences and link new information to what they already know. The investigators will compare performance on a memory task between stressed and non-stressed participants. This memory task requires people to integrate knowledge across learning experiences (think: having to "connect the dots", draw inferences, and generalize your knowledge to new situations and scenarios). Cortisol, the brain's primary stress hormone, will be measured at multiple points throughout the study to measure stress levels. The investigators hypothesize that:
This research has broad implications for understanding how stress impacts the ability to learn and retain new information, particularly in high-stress environments like schools and workplaces. Additionally, this work may provide insights into the cognitive difficulties experienced by individuals with psychiatric disorders, where stress can worsen memory and learning challenges.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Acute Stress Condition | Experimental | Participants randomized to the acute stress condition will complete the Trier Social Stress Test (TSST), a validated experimental method for inducing acute psychosocial stress. This condition will allow for us to evaluate our primary hypothesis. |
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| Non-Stress Control Condition | Sham Comparator | Participants randomized to the non-stress control condition will complete a non-stressful task designed to parallel the structure of the Trier Social Stress Test without eliciting acute stress. |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Acute Stress | Behavioral | Participants randomized to the acute stress condition will complete the Trier Social Stress Test (TSST), a validated experimental method for inducing acute psychosocial stress. The TSST consists of a brief anticipation period followed by a 5-minute mock job interview and a 5-minute surprise mental arithmetic task, performed in front of a neutral panel of judges in professional attire. |
| Measure | Description | Time Frame |
|---|---|---|
| Performance on A-C inference trials in the Paired Associative Inference Task | Performance on A-C inference trials of the memory task assesses memory integration across overlapping learning experiences. | During the participant's study visit, anticipated 1-2 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Performance on directly learned pairs (A-B and B-C) in the Paired Associative Inference Task | Performance on directly learned pairs (A-B and B-C) evaluates basic associative memory. | During the participant's study visit, anticipated 1-2 hours |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Corey A Fernandez, PhD, Neuroscience | Nevada State University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Nevada State University | Henderson | Nevada | 89002-9776 | United States |
De-identified data, including demographic and outcome measures, will be made available to qualified researchers upon request after publication of findings. Data will be shared under a data use agreement via a secure repository such as Open Science Framework (OSF).
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| ID | Term |
|---|---|
| D011581 | Psychological Tests |
| ID | Term |
|---|---|
| D004191 | Behavioral Disciplines and Activities |
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| Non-Stress Control Task | Behavioral | Participants randomized to the control condition will complete a non-stressful task designed to parallel the structure of the Trier Social Stress Test without eliciting acute stress. They will have a brief anticipation period followed by a 5-minute description of their typical day or favorite hobby. This task is conducted without an evaluative panel, minimizing the potential for stress or anxiety. |
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