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The current study is designed to investigate the analgesic potentials of two modalities of abdominal blocks where local anesthetics is injected in the fascial planes of the abdominal muscles to anesthetize the nerves supplying the abdomen in patients undergoing upper abdomial surgeries.
the two modalities are the rectus sheath block (RSB) and the external oblique intercostal plane block (EOIPB). The investigators are going to use the ultrasound to identify the muscles and inject the local anesthetics. The investigators suggest that the EOIPB might provide better pain control when compared to RSB.
Fascial plane blocks emerge as an appealing technique to provide good intraoperative and postoperative analgesia in patients undergoing upper abdominal surgeries. Such techniques have the benefit of decreasing opioids use and consequently reducing the like hood of their side effects.
Ultrasound guided rectus sheath Block (RSB) targets the terminal branches of thoracic nerves thus providing analgesia for midline abdominal incisions.
Ultrasound guided external oblique intercostal plane block (EOIPB), a relatively new technique, targets the lateral cutaneous branches of the thoracoabdominal nerves providing analgesia for anterolateral and upper median plane of the abdomen.
Studies Comparing both techniques are deficient, that is why the investigators designed the current study to evaluate and compare the analgesic efficacy of both techniques in upper abdominal surgeries namely Whipple operation and total gastrectomy.
The study is a randomized controlled double blinded trial comprising two groups. The RSB group will receive bilateral ultrasound guided rectus sheath block with 20ml of 0.25% bupivacaine on each side. The EOIB group will receive bilateral ultrasound guided External oblique intercostal plane block with 20ml of 0.25% bupivacaine on each side as well. Both blocks will be performed after administering general anesthesia.
The main endpoint of the study is the time to first request for rescue analgesia.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| RSB | Active Comparator | Bilateral rectus sheath block for patients undergoing upper abdominal surgeries |
|
| EOIPB | Experimental | Bilateral External oblique intercostal plane block for patients undergoing upper abdominal surgeries |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Ultrasound guided Rectus sheath block | Procedure | After receiving general anesthesia, bilateral ultrasound guided rectus sheath block with 20 ml of 0.25% bupivacaine on each side will be administered to 20 patients undergoing upper abdominal surgeries namely whipple operation and total gastrectomy |
| Measure | Description | Time Frame |
|---|---|---|
| Time to first request for rescue analgesia | Time from end of surgery to first dose of morphine administered | Time in hours from end of surgery to first dose of morphine administered up to 24 hours postoperatively |
| Measure | Description | Time Frame |
|---|---|---|
| Fentanyl consumption | Intraoperative fentanyl consumption | From the start of the surgery till the end in micogram/Kg |
| Postoperative morphine consumption | Total morphine consumption (mg) in the first 24hrs after surgery |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Mohamed Abd El Fattah, Associate professor | National Cancer Institute, Egypt | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Kasr El Ainy | Cairo | Egypt | ||||
| National Cancer institute |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 34626112 | Result | Elsharkawy H, Kolli S, Soliman LM, Seif J, Drake RL, Mariano ER, El-Boghdadly K. The External Oblique Intercostal Block: Anatomic Evaluation and Case Series. Pain Med. 2021 Nov 26;22(11):2436-2442. doi: 10.1093/pm/pnab296. | |
| 35999334 | Result | Ohgoshi Y, Kawagoe I, Ando A, Ikegami M, Hanai S, Ichimura K. Novel external oblique muscle plane block for blockade of the lateral abdominal wall: a pilot study on volunteers. Can J Anaesth. 2022 Oct;69(10):1203-1210. doi: 10.1007/s12630-022-02310-4. Epub 2022 Aug 23. |
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The detailed protocol describing the techniques used in the study and the anesthetic conduct and the outcome measures.
The statistical plan to analyze the different outcome measures.
IPD can be available 2 months after completion of the study
IPD can be accessed from the authors by journals considering the study for publication and upon reasonable request from other investigators
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| ultrasound guided external oblique intercostal plane block | Procedure | After receiving general anesthesia, bilateral ultrasound guided external oblique intercostal plane block with 20 ml of 0.25% bupivacaine on each side will be administered to 20 patients undergoing upper abdominal surgeries namely whipple operation and total gastrectomy |
|
| from the time numerical rating scale exceeds 3 and till 24 hours after the end of the surgery |
| Pain score | Pain score using Numerical rating Scale (NRS)between 0 and 10, Zero means no pain and ten means the worst pain | from the time of recovery immediately in the postoperative period and then at 30 minutes, 1 hour, 2 hours, 4 hours, 6 hours, 12 hours and 24 hours postoperatively |
| Patient satisfaction of analgesia | Degree of patient satisfaction will be assessed on a 5-point Likert scale patient satisfaction (1, extremely dissatisfied; 2, unsatisfied; 3, neutral; 4, satisfied ; 5, extremely satisfied) | 2 hours after recovery from anesthesia |
| Incidence of postoperative nausea and vomiting | The number of patients suffering from postoperative nausea and vomiting in both groups | From the recovery of anesthesia and up to 24 hours postoperatively |
| Cairo |
| Egypt |
| 37635853 | Result | Abdildin Y, Tapinova K, Salamat A, Shaimakhanov R, Aitbayev A, Viderman D. Rectus Sheath Block in Abdominal Surgery: A Systematic Review with Meta-Analysis. Rom J Anaesth Intensive Care. 2023 Apr 20;30(1):43-50. doi: 10.2478/rjaic-2023-0006. eCollection 2023 Apr. |
| 29423579 | Result | Cho S, Kim YJ, Jeong K, Moon HS. Ultrasound-guided bilateral rectus sheath block reduces early postoperative pain after laparoscopic gynecologic surgery: a randomized study. J Anesth. 2018 Apr;32(2):189-197. doi: 10.1007/s00540-018-2457-0. Epub 2018 Feb 8. |
| 34739706 | Result | Howle R, Ng SC, Wong HY, Onwochei D, Desai N. Comparison of analgesic modalities for patients undergoing midline laparotomy: a systematic review and network meta-analysis. Can J Anaesth. 2022 Jan;69(1):140-176. doi: 10.1007/s12630-021-02128-6. Epub 2021 Nov 5. |