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The purpose of this research is to investigate the impact of acute pain, induced using an experimental pain paradigm of capsaicin paired with heat, on implicit locomotor learning and its retention in older adults.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| No Pain | No Intervention | Will receive no intervention. | |
| Pain | Experimental | Will receive capsaicin and heat combined to induce acute pain. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Capsaicin 0.1% cream combined with a heat pack and applied to the lower leg | Behavioral | Capsaicin is applied to the skin of one of the lower legs, then covered with a heat pack that is secured to the leg with self-adhesive wrap. |
| Measure | Description | Time Frame |
|---|---|---|
| Learning magnitude | Step length asymmetry averaged over the last 25 strides of the practice period on day 1. | End of day 1 |
| Retention magnitude | Step length asymmetry averaged over the first 4 strides of the re-adaptation period on day 2. | Beginning of day 2. |
| Forgetting index | Difference between retention magnitude and learning magnitude. | End of day 1 and beginning of day 2. |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Ashley Fath | Contact | 302-283-9936 | RNP-Lab@udel.edu |
| Name | Affiliation | Role |
|---|---|---|
| Susanne Morton | University of Delaware | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Health Sciences Complex | Recruiting | Newark | Delaware | 19713 | United States |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D002211 | Capsaicin |
| ID | Term |
|---|---|
| D053284 | Polyunsaturated Alkamides |
| D000577 | Amides |
| D009930 | Organic Chemicals |
| D000475 | Alkenes |
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| D006839 |
| Hydrocarbons, Acyclic |
| D006838 | Hydrocarbons |
| D002396 | Catechols |
| D010636 | Phenols |
| D001555 | Benzene Derivatives |
| D006841 | Hydrocarbons, Aromatic |
| D006844 | Hydrocarbons, Cyclic |
| D012991 | Solanaceous Alkaloids |
| D000470 | Alkaloids |
| D006571 | Heterocyclic Compounds |
| D005229 | Fatty Acids, Monounsaturated |
| D005231 | Fatty Acids, Unsaturated |
| D005227 | Fatty Acids |
| D008055 | Lipids |