KARMA study is a hospital-based research study looking at how different ways of delivering kidney support therapy (CRRT) affect patients who are critically ill. In some cases, the kidneys may temporarily stop working in very sick patients, and machines are used to filter the blood. This study is exploring whether the way the investigators use these machines - how early to start, how much treatment to give, and what type to choose - makes a difference in how well the kidneys recover. By learning from many hospitals and hundreds of patients, KARMA hopes to improve treatment choices and help patients regain their kidney function faster.

Inclusion Criteria:

• Acute kidney injury
• ICU administration

Exclusion Criteria:

• Pre-existing CKD (GFR < 30 ml/min/1,73m2)
• Chronic dialysis-dependent end-stage renal failure

By analyzing the variation in therapeutic approaches across centers-including convection- and diffusion-based techniques, dose intensity, and initiation thresholds-KARMA study aims to identify best practices that promote renal recovery and reduce the transition to acute kidney disease. The study integrates clinical, biochemical, and outcome metrics to support a precision medicine framework in critical care nephrology and in critically ill patients with acute kidney injury.

Specific IPD including information like a participant's age, sex, treatment received, and specific outcomes will be shared

Start date: December 25, 2025 End date: October 25, 2026