Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT ( KETZEREI )

A Randomized Controlled Study Investigating Standard Dose Continuous Renal Replacement Therapy (CRRT) Versus Low-Dose CRRT - The "Ketzerei" Trial

Acute kidney injury (AKI) is a well-recognized complication in critically ill patients, which often leads to the necessity of mechanical kidney support (CRRT).

In current therapeutic regimes, CRRT is used to strictly prevent azotaemia. Thus recent clinical observations, as well as data from animal testing suggest a link between controlled azotaemia and faster renal recovery in AKI patients.

The aim of the study is to improve renal recovery.

Inclusion Criteria:

• Adult patients (age ≥18 years)
• Critically ill patients with AKI + in need of CRRT
• Written informed consent

Exclusion Criteria:

• Chronic dialysis dependency
• Chronic kidney disease with estimated glomerular filtration rate (eGFR) <30 ml/min/1.73m²
• severe liver cirrhosis (Child-pugh C)
• severe acidosis (pH < 7,20 at study enrolment)
• severe hyperkalaemia (> 6mmol/l)
• Pregnancy or breastfeeding
• persons held in an institution by legal or official order
• Dependency on the investigator or center