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The purpose of this research is to determine the effects of food on brain and stomach activity in persons with and without spinal cord injury (SCI).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Pre-load Condition Meal Group | Experimental | Participants will be in this group for up to 2 weeks. |
|
| Ad-libitum Condition Meal Group | Active Comparator | Participants will be in this group for up to 2 weeks. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Preload condition | Other | Participants will consume a fixed compulsory preload meal of Campbell's Tomato soup (~300 grams) 30 minutes after the baseline assessments. Fifteen minutes after consuming the preload meal, participants will receive the ad libitum test meal, consisting of a pre-weighed serving of Stouffer's Macaroni and Cheese (~700 g).The pre-load condition will be completed at only one of two visits. Participation will be up to 2 weeks with the visits separated by up to 2 weeks. Duration for the pre-load condition visit will be up to 6 hours |
| Measure | Description | Time Frame |
|---|---|---|
| Phase amplitude coupling (PAC) strength | Gut-brain connectivity will be assessed using phase-amplitude coupling (PAC) to examine the interaction between gastric electrical oscillations and cortical rhythms. PAC will be calculated from electrophysiological raw data to produce one unitless value ranging from -1 to 1, for each subject. The higher the value, the greater the gut-brain connectivity/PAC strength. | up to 2 weeks |
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Inclusion Criteria, SCI and Controls
Exclusion Criteria, SCI and Controls
SCI-specific Eligibility Criteria
Inclusion Criteria, SCI Only
Exclusion Criteria, SCI Only
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Guillermo Mederos | Contact | 305-243-4518 | gxm1228@med.miami.edu | |
| Gary J Farkas, PhD | Contact | 305-243-4518 | gjf50@med.miami.edu |
| Name | Affiliation | Role |
|---|---|---|
| Gary J Farkas, PhD | University of Miami | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Miami - Miami Project to Cure Paralysis | Recruiting | Miami | Florida | 33136 | United States |
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| ID | Term |
|---|---|
| D013119 | Spinal Cord Injuries |
| ID | Term |
|---|---|
| D013118 | Spinal Cord Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D020196 | Trauma, Nervous System |
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| Ad-libitum control condition | Other | Participants will only consume the ad libitum test meal, which consists of a pre-weighted serving of Stouffer's Macaroni and Cheese (~700 g). The ad-libitum meal will be consumed at both visits. Participation will be up to 2 weeks with the visits separated by up to 2 weeks. The ad-libitum control condition visit will take up to 2 hours. |
|
| D014947 | Wounds and Injuries |