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| ID | Type | Description | Link |
|---|---|---|---|
| NL87069.068.24 | Other Identifier | Toetsing Online |
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| Name | Class |
|---|---|
| National Cattlemen's Beef Association, a contractor to the Beef Checkoff | INDUSTRY |
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Muscles are composed out of proteins. These proteins in turn are composed out of smaller building blocks, called amino acids. By consuming a sufficient amount of dietary protein, a sufficient amount of amino acids become available to build new muscle proteins. The body's ability to build these new muscle proteins is of great importance to maintain muscle strength and function.
Previous research suggests that a meal containing proteins from meat results in a better stimulation of the body's ability to build muscle proteins, when compared to a meal containing only plant-based proteins. However, these previous studies have only been performed following the ingestion of a single meal. As a result it is currently unknown how the muscles respond to a more prolonged ingestion of a diet containing animal/meat products, in comparison to a plant-based diet. Therefore, this study aims to investigate how fast new muscle proteins are being build when consuming a diet containing animal/meat products, in comparison to a plant-based (vegan) diet.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| MEAT-PLANT | Experimental | Participants will be subjected to a 10-day diet containing meat and animal products, followed by a 10-day diet containing plant products. During the interventional period participants will perform unilateral lower limb resistance exercise. |
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| PLANT-MEAT | Experimental | Participants will be subjected to a 10-day diet containing plant products, followed by a 10-day diet containing meat and animal products. During the interventional period participants will perform unilateral lower limb resistance exercise. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Meat diet | Other | Participants will be subjected to a 10-day diet containing meat and animal products. During the interventional period participants will perform unilateral lower limb resistance exercise. |
| Measure | Description | Time Frame |
|---|---|---|
| Integrated muscle protein synthesis rate in rested leg | The main study endpoint will be the difference in muscle protein synthesis rates in the non-exercised leg, between the plant-based diet and the meat diet, expressed as FSR (%/day). | The 2 intervention periods over which FSR is determined will each last 10 days |
| Measure | Description | Time Frame |
|---|---|---|
| Integrated muscle protein synthesis rate in exercised leg | The difference in muscle protein synthesis rates in the exercised leg, between the plant-based diet and the meat diet, expressed as FSR (%/day). | The 2 intervention periods over which FSR is determined will each last 10 days |
| Blood glucose |
| Measure | Description | Time Frame |
|---|---|---|
| Participant characteristics | Participants characteristics at baseline will be reported as descriptives. This includes: Age, sex, body mass, height, BMI, Body composition as assed by DEXA scan, habitual dietary intake, habitual physical activity. | At baseline, before start interventional period |
| Muscle histology characteristics |
Inclusion Criteria:
Exclusion Criteria:
Healthy older males and females are eligible to participate
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Philippe Pinckaers, PhD | Contact | +31 43 388 22 15 | philippe.pinckaers@maastrichtuniversity.nl |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Maastricht University Medical Centre+ | Recruiting | Maastricht | Limburg | 6229ER | Netherlands |
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Randomized, counter-balanced, cross-over design, researchers and participants are not blinded, analysts are blinded.
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| Plant diet | Other | Participants will be subjected to a 10-day diet containing plant products. During the interventional period participants will perform unilateral lower limb resistance exercise. |
|
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The difference in plasma glucose concentrations will be determined following the MEAT vs PLANT diet |
| The 2 intervention periods after which the outcomes are determined will each last 10 days |
| Blood insulin | The difference in plasma, insulin, will be determined following the MEAT vs PLANT diet | The 2 intervention periods after which the outcomes are determined will each last 10 days |
| Blood lipid profile | The difference in blood lipid profile will be determined following the MEAT vs PLANT diet | The 2 intervention periods after which the outcomes are determined will each last 10 days |
| Blood inflammatory markers | The difference in blood inflammatory markers will be determined following the MEAT vs PLANT diet | The 2 intervention periods after which the outcomes are determined will each last 10 days |
| Blood amino acid profile | The difference in plasma amino acid profile will be determined following the MEAT vs PLANT diet | The 2 intervention periods after which the outcomes are determined will each last 10 days |
| Blood pressure | The difference in blood pressure (both systolic and diastolic) will be determined following the MEAT vs PLANT diet | The 2 intervention periods after which the blood pressure is determined will each last 10 days |
Muscle histology characteristics at baseline will be reported as descriptive. |
| At baseline, before start interventional period |
| Muscle signaling proteins | The difference in muscle signaling protein between the plant-based diet and the meat diet. | The 2 intervention periods over which muscle signaling proteins are determined will each last 10 days |
| Dietary intake | The dietary intake during the 2 interventional periods will be compared. Measured by dietary intake records | The 2 intervention periods that will be compared will each last 10 days |
| Fecal Microbiome | The Fecal microbiome following the 2 interventional periods will be compared, measured in fecal samples | The 2 intervention periods that will be compared will each last 10 days |
| Step count | The step count during the 2 interventional periods will be compared. Measured by an Actigraph activity monitor | The 2 intervention periods that will be compared will each last 10 days |
| Subjective feeling | Satiety, muscle soreness, and gastro-intestinal complaints scores during the 2 interventional periods will be compared. Measured by visual analog scale questionnaires. The left side of the 100mm scale represents a score of 0 (= no complaints). The right side of the 100mm scale represents a score of 100 (=severe complaints) | The 2 intervention periods that will be compared will each last 10 days |
| ID | Term |
|---|---|
| D066273 | Diet, Western |
| D000095500 | Diet, Plant-Based |
| D000067269 | Diet, Vegan |
| ID | Term |
|---|---|
| D004032 | Diet |
| D009747 | Nutritional Physiological Phenomena |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D004035 | Diet Therapy |
| D044623 | Nutrition Therapy |
| D013812 | Therapeutics |
| D014676 | Diet, Vegetarian |
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