The Effect of Aerobic Exercise on Selective Biomarkers of Patients With Cancer

The Effect of Supervised Aerobic Exercise on Adipokine and Myokine Biomarkers in Patients With Cancer During Systemic Chemotherapy

This study is a single-blinded, prospective, controlled trial aiming to evaluate the effect of supervised aerobic exercise on adipokine and myokine biomarkers in patients with breast or colon cancer during their systemic chemotherapy.

To determine the effect of aerobic exercise on adipokine and myokine biomarkers such as Interleukin-6 (IL-6), Irisin, Leptin and Adiponectin in the blood of breast or colon cancer patients receiving chemotherapy compared to ones who did not exercise during their systemic chemotherapy.

Patients who were diagnosed with solid type of cancer specifically focusing on breast or colon cancer will be recruited either to the exercise group (EG) or control group (CG) during their systemic chemotherapy. An individualized supervised resistive aerobic exercise which will be performed via stationary resistive biycle ergometer will be implemented along with the chemotherapy process for EG.

Each exercise session will be performed 2 times per week for at least 12 weeks (can be extended up to 24 weeks) during chemotherapy.

Exercise intensity will be set as submaximal, 50-70% of heart rate reserve, and each session will be lasted 35 minutes.

All exercise sessions will be supervised by the researchers to avoid potential side effects.

5 cc venous blood samples will be collected before the first and last chemotherapy infusions (for both EG and CG). The samples will be blinded to the analyzers did not know which group the samples belonged to.

Inclusion Criteria:

• Having been diagnosed with solid type of cancer
• Being candidate for systemic chemotherapy
• Being volunteer to participate in an exercise program
• Aged between 18-70 years old

Exclusion Criteria:

• Having 2 or above grades according to the Eastern Cooperative Oncology Group (ECOG) performance status
• Having mental and/or cognitive deficits
• Ongoing medical and/or surgical (if any) complications
• Having neurological/orthopedical and/or severe respiratory dysfunctions
• Having any condition which corresponds to the contraindication of exercise (i.e. advanced stages, distant metastasis, infection)
• Having unstable vital parameters or having regularly used pharmacological interventions