Acute Effect of modeRate-intensity aerOBIc Exercise on Colon Cancer Cell Growth

Effect of a Single Bout of Moderate-intensity Aerobic Exercise on Colon Cancer Cell Growth in Vitro

This study involves drawing blood samples from men before and after they perform 30-minutes of moderate-intensity aerobic exercise. The investigators will evaluate whether adding the exercise serum to colon cancer cells in a dish can reduce the growth of the cells compared to the resting serum.

Note: serum is the liquid part of the blood that carries hormones and metabolites around the body.

Regular exercise is associated with a reduced risk of developing colon cancer. However, the mechanisms underpinning the anti-cancer effect of exercise are not yet fully understood. A recent theory suggests that each time you exercise, the short-lasting spikes in circulating hormones can suppress the growth of cancer cells. Hence, every exercise bout could have a direct anti-cancer effect.

This study will recruit men with an increased of colon cancer and explore whether incubating colon cancer cells with serum collected after a bout of moderate-intensity aerobic exercise influences cell viability in vitro.

Inclusion Criteria:

• Age ≥ 50 years
• BMI ≥ 25 kg/m2 and/or waist circumference of ≥ 94 cm
• Male
• Participating in less than 30 min of planned, structured, moderate to vigorous-intensity physical activity on three or more d·wk-1 for the last three months

Exclusion Criteria:

• Any absolute or relative contraindication to exercise testing, as determined by the American College of Sports Medicine
• Any sign/symptom of cardiovascular, metabolic or renal disease
• Known cardiovascular, metabolic or renal disease without written medical clearance from physician
• Resting hypertension (≥160 mmHg systolic and/or ≥90 mmHg diastolic)
• Chronic obstructive pulmonary disease and/or asthma with peak respiratory flow < 300 l/min
• Previous stroke or transient ischemic attack
• Epilepsy or aneurysm (large vessel or cerebral)
• Previous or current treatment for malignancy
• Clotting disorder
• Taking beta-adrenergic blocking agents
• Resting heart rate ≥ 100 bpm
• Musculoskeletal, neurological, anthropometric, or rheumatoid conditions that makes it not possible to pedal a bicycle and/or would be worsened due to exercise
• Body mass > 150 kg