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this study aims to compare between effects of lidocaine and ketamine infusion on postoperative analgesia in patients undergoing thyroidectomy.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| group L : will receive lidocaine | Active Comparator | lidocaine Infusion will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy |
|
| group k : will receive ketamine | Active Comparator | Ketamine Infusion will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy |
|
| group c: will receive .9% saline | Placebo Comparator | .9% saline will be given for Postoperative Analgesia in Patients Undergoing Thyroidectomy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| group L : will receive lidocaine | Drug | group L : will receive 1.5 mg/kg bolus of iv lidocaine 10 minutes before anaesthesia induction then continuous iv infusion rate 1.5 mg / kg / h |
| Measure | Description | Time Frame |
|---|---|---|
| the effect of perioperative intravenous lidocaine and ketamine infusion for postoperative analgesia in patients undergoing thyroidectomy | postoperative pain by Numerical Rating Scale (NRS) Zero means no pain and ten means worst pain | 24 hours posftoperative |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mario N Ishak, Resident | Contact | 01210609798 | marionashaat63@gmail.com | |
| Abdel Rahman H Abdel Rahman, Professor | Contact | 01120320258 |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Sohag university hospital | Recruiting | Sohag | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 37296896 | Background | Ludwig B, Ludwig M, Dziekiewicz A, Mikula A, Cisek J, Biernat S, Kaliszewski K. Modern Surgical Techniques of Thyroidectomy and Advances in the Prevention and Treatment of Perioperative Complications. Cancers (Basel). 2023 May 26;15(11):2931. doi: 10.3390/cancers15112931. | |
| 39881145 | Background | Javidi S, Sadrizadeh S, Sadrizadeh A, Bonakdaran S, Jarahi L. Postoperative complications and long-term outcomes after total and subtotal thyroidectomy: a retrospective study. Sci Rep. 2025 Jan 29;15(1):3705. doi: 10.1038/s41598-024-79860-8. |
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| ID | Term |
|---|---|
| D013959 | Thyroid Diseases |
| ID | Term |
|---|---|
| D004700 | Endocrine System Diseases |
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| ID | Term |
|---|---|
| D012965 | Sodium Chloride |
| ID | Term |
|---|---|
| D002712 | Chlorides |
| D006851 | Hydrochloric Acid |
| D017606 | Chlorine Compounds |
| D007287 | Inorganic Chemicals |
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| group k : will receive Ketamine | Drug | patients will receive .25 mg / kg bolus of iv ketamine 10 minutes before anaesthesia induction then continuous iv infusion of ketamine at .25 mg /kg /h |
|
| group c: will recieve .9% saline | Drug | group c will be injected with equivalent volumes and rates of .9% saline using the same application scheme as the lidocaine and ketamine as a control group |
|
| 38022245 | Background | Jain SN, Lamture Y, Krishna M. Enhanced Recovery After Surgery: Exploring the Advances and Strategies. Cureus. 2023 Oct 17;15(10):e47237. doi: 10.7759/cureus.47237. eCollection 2023 Oct. |
| D017670 |
| Sodium Compounds |