Molecular and Cellular Profiling of Uterine Lavage Collected During Gynecologic Surgery

Exploring the Molecular and Cellular Composition of Uterine Lavage Specimens Collected at the Time of Gynecologic Surgery.

This study is a designed as a to test the clinical and technical feasibility of using this novel uterine lavage collection catheter to collected UL samples from up to 50 individuals undergoing gynecologic surgery and to describe the cellular composition of these samples. In order to do this, it is a prospective consecutively-enrolled cohort of 50 participants, all of who will receive the intervention of uterine lavage collection.

Inclusion Criteria:

• Undergoing gynecologic surgery with Stanford Healthcare
• Intact uterus and cervix
• At least one intact fallopian tube and ovary (on the same side)
• Aged 18 years or older
• Ability to understand and the willingness to provide written informed consent.

Exclusion Criteria:

• Known endometrial or cervical cancer or endometrial or cervical intraepithelial neoplasia
• Status post bilateral salpingectomy or tubal ligation
• Lack of consenting capacity
• Positive preoperative pregnancy test
• Active uterine bleeding (i.e. menses, etc.)
• Intrauterine device in place
• Non-English speaking (requires interpretor)