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This study is a designed as a to test the clinical and technical feasibility of using this novel uterine lavage collection catheter to collected UL samples from up to 50 individuals undergoing gynecologic surgery and to describe the cellular composition of these samples. In order to do this, it is a prospective consecutively-enrolled cohort of 50 participants, all of who will receive the intervention of uterine lavage collection.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Single Group | Experimental | Participants undergoing gynecologic surgery who agree to uterine lavage collection intraoperatively for molecular and cellular analysis. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Uterine Lavage | Procedure | Saline is introduced into the uterine cavity and retrieved during surgery to collect cells and fluid for downstream molecular and cellular analyses. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Characterization of cellular composition in uterine lavage fluid | Quantification and classification of cell types obtained from uterine lavage specimens using cytology and/or flow cytometry. | At time of gynecologic surgery |
| Measure | Description | Time Frame |
|---|---|---|
| Molecular profiling of uterine lavage specimens | Analysis of RNA, DNA, or protein expression profiles in collected lavage fluid. | At time of surgery |
| Detection of inflammatory biomarkers in uterine lavage |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Rozelle Laquindanum | Contact | (650) 724-9948 | rlaquind@stanford.edu |
| Name | Affiliation | Role |
|---|---|---|
| James Ford, MD | Stanford University | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Stanford University | Recruiting | Palo Alto | California | 94304 | United States |
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| ID | Term |
|---|---|
| D005831 | Genital Diseases, Female |
| D014594 | Uterine Neoplasms |
| ID | Term |
|---|---|
| D052776 | Female Urogenital Diseases |
| D005261 | Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D000091662 | Genital Diseases |
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Measurement of cytokines or other markers associated with uterine immune status or pathology.
| At time of surgery |
| D005833 | Genital Neoplasms, Female |
| D014565 | Urogenital Neoplasms |
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D014591 | Uterine Diseases |