Uterine Lavage to Detect Ovarian Cancer Risk

Collection of Uterine Lavage in High-Risk Patients as a Potential Biomarker for Ovarian Cancer Risk

This clinical trial develops a non-surgical approach using uterine lavage samples to screen for progression to ovarian cancer in high-risk patients carrying BRCA mutations. Women with inherited mutations in the BRCA1 and BRCA2 genes (BRCA carriers) have a much higher lifetime risk of developing ovarian cancer. Currently there are no effective ovarian cancer screening or early detection tests for BRCA carriers. Uterine lavage is a procedure that uses saline to rinse and collect cells from the fallopian tube. Molecular analysis of these samples may help proactively detect genetic alterations that are indicative of progression to ovarian cancer in women with BRCA mutations.

OUTLINE:

Patients undergo uterine lavage prior to their standard of care (SOC) risk-reduction surgery and uterine lavage samples undergo molecular analysis on study.

Inclusion Criteria:

• > 18 years of age
• Have a pathogenic BRCA1 or BRCA2 germline variant
• Planned risk-reduction surgery
• Presence of uterus and at least one fallopian tube

Exclusion Criteria:

• Prior tubal ligation
• Prior history of known ovarian or endometrial cancer