Upper Body Subcutaneous Exosome Release in Response to a Meal in Obesity

Upper Body Subcutaneous Adipose Tissue Outflow Response to a Meal

The purpose of this study is to understand the specific outflow and difference between normal weight and volunteers with obesity of upper body subcutaneous adipose tissue in response to a mixed meal challenge by site specific cannulation of the superior epigastric vein. We will characterize the exosome signatures in response to a meal and compare to the exosome signature of arterialized venous plasma samples.

Inclusion Criteria:

• All women must be premenopausal

Exclusion Criteria:

• Participants taking medications know to affect blood flow (statins, β-blockers) or fatty acid or adipose tissue metabolism (TZDs, high dose fish oil supplements)
• Diabetes, history of cardiovascular disease
• Allergy to lidocaine
• Post-menopausal women
• Pregnant