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This study investigates the impact of four standard of care, monitored group exercise regimens (resistance training) on conditioning and hypertrophy in women previously treated for breast cancer. The study will compare two conditioning regimens (6-12-25 and 8x8) and two hypertrophy regimens (5/5/5 cluster sets and double training) to assess changes in VO2 max, muscle mass, and fat mass.
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 6-12-25 Training Regimen | Other | A conditioning regimen involving three exercises performed consecutively with minimal rest. Includes 4-6 repetitions at 4-0-1-0 tempo, 10-12 repetitions at 3-0-1-0 tempo, and 20-25 repetitions at 2-0-1-0 tempo. | ||
| 8x8 Training Regimen | Other | A conditioning regimen optimizing high volume with short rest periods. Six exercises are performed consecutively with a 2-0-1-0 tempo and no rest between sets. | ||
| 5/5/5 Cluster Set Training Regimen | Other | A hypertrophy regimen where an individual performs 5 repetitions at a tempo of 4 seconds during the eccentric movement of the exercise, while performing the concentric motion in 1 second then resting for 20 seconds and repeating the sequence two additional times to total three clusters of 5 repetitions. | ||
| Double Training Regimen | Other | A hypertrophy regimen adding an additional set of lesser repetitions for a specified exercise at the end of a tri-set of exercises. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in VO2 max | Change in maximal oxygen consumption (VO2 max) measured during and after each exercise regimen. | Measured monthly during the 5-month exercise program at weeks 4, 8, 12, 16, and 20. |
| Change in Muscle and Fat Mass | Change in muscle mass and fat mass in pounds as measured by InBody 970. | Baseline, at the completion of the 5-month exercise program (Week 20), and monthly during the exercise program at weeks 4, 8, 12, and 16. |
| Change in Muscle and Fat Mass | Change in muscle mass and fat mass in pounds as measured by ultrasound. | Baseline, at the completion of the 5-month exercise program (Week 20), and monthly during the exercise program at weeks 4, 8, 12, and 16. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Hand Grip Strength | Measurement of hand grip strength using a dynamometer to assess upper body strength and function. | Baseline, at the completion of the 5-month exercise program (Week 20), and monthly during the exercise program at weeks 4, 8, 12, and 16. |
| Change in Psychology Questionnaire Scores |
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Inclusion Criteria:
Exclusion Criteria:
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Participants will be recruited via convenience sampling from the Study Investigators' practice patient population, referrals from other physicians' practices, or identifiable medical record review (e.g., EPIC).
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Clinical Trials Contact | Contact | 412-330-6151 | ctgov@ahn.org |
| Name | Affiliation | Role |
|---|---|---|
| Colin Champ | AHN Radiation Oncology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Allegheny General Hospital | Recruiting | Pittsburgh | Pennsylvania | 15212 | United States |
Upon reasonable request the investigators plan to share unidentified data
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Assessment of psychological well-being, including confidence, motivation (intrinsic & extrinsic), anxiety, and depression, using a Psychological Screen for Strength Training questionnaire. The responses to the variables will be calculated. The rating scale will be calculated 0-3. Not at all (0), some of the time (1), most of the time (2), and all the time (3). |
| Baseline, at the completion of the 5-month exercise program (Week 20), and monthly during the exercise program at weeks 4, 8, 12, and 16. |
| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D001943 | Breast Neoplasms |
| D009043 | Motor Activity |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D001519 | Behavior |
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