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In this pilot study, the investigators will assess the changes in myokine production based on several different exercise regimens.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Conditioning Regimen Group | Experimental |
| |
| Strength Regimen Group | Experimental |
| |
| Hypertrophy Regimen Group | Experimental |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Conditioning Resistance Training | Behavioral | Participants in this group will perform a conditioning regimen from the EXERT-BCHC protocol, specifically described as "double training". |
| Measure | Description | Time Frame |
|---|---|---|
| Change in Myokine Production After First Exercise Session | Quantification of a panel of 15 myokines (IL-5, IL-1ra, LIF, Irisin, SPARC, Decorin, Oncostatin M, Myostatin, Follistatin, Apelin, Fibroblast Growth Factor 21 (FGF21), Cathepsin-B, IL-15, METRNL, Myonectin) in both serum and tear samples. The change from pre-exercise to post-exercise levels will be determined. | Immediately before and immediately after the first exercise session. |
| Change in Myokine Production After Final Exercise Session of Each Week | Quantification of a panel of 15 myokines (IL-5, IL-1ra, LIF, Irisin, SPARC, Decorin, Oncostatin M, Myostatin, Follistatin, Apelin, Fibroblast Growth Factor 21 (FGF21), Cathepsin-B, IL-15, METRNL, Myonectin) in both serum and tear samples for each group. The change from pre-exercise to post-exercise levels at the end of each week will be determined. | Immediately before and immediately after the final exercise session of weeks 1, 2, 3, and 4. |
| Change in Myokine Production After Final Exercise Session of the Month (End of Study) | Quantification of a panel of 15 myokines (IL-5, IL-1ra, LIF, Irisin, SPARC, Decorin, Oncostatin M, Myostatin, Follistatin, Apelin, Fibroblast Growth Factor 21 (FGF21), Cathepsin-B, IL-15, METRNL, Myonectin) in both serum and tear samples for each group. The change from pre-exercise to post-exercise levels at the culmination of the 4-week exercise period will be determined. | Immediately before and immediately after the final exercise session of week 4 (end of the 4-week exercise regimen). |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Clinical Trials Contact | Contact | 412-330-6151 | ctgov@ahn.org |
| Name | Affiliation | Role |
|---|---|---|
| Colin Champ, MD | AHN Radiation Oncology | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| AHN Allegheny General Hospital | Pittsburgh | Pennsylvania | 15212 | United States |
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| Strength Resistance Training | Behavioral | Participants in this group will perform a strength regimen from the EXERT-BCHC protocol, specifically described as "8x8". |
|
| Hypertrophy Resistance Training | Behavioral | Participants in this group will perform a hypertrophy regimen from the EXERT-BCHC protocol, specifically described as the "control arm". |
|
| ID | Term |
|---|---|
| D009369 | Neoplasms |
| D001943 | Breast Neoplasms |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
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| ID | Term |
|---|---|
| D055070 | Resistance Training |
| ID | Term |
|---|---|
| D005081 | Exercise Therapy |
| D012046 | Rehabilitation |
| D000359 | Aftercare |
| D003266 | Continuity of Patient Care |
| D005791 | Patient Care |
| D013812 | Therapeutics |
| D026741 | Physical Therapy Modalities |
| D064797 | Physical Conditioning, Human |
| D015444 | Exercise |
| D009043 | Motor Activity |
| D009068 | Movement |
| D009142 | Musculoskeletal Physiological Phenomena |
| D055687 | Musculoskeletal and Neural Physiological Phenomena |
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