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Radiodermatitis is a major problem in oncologic patients, fat grafts previously used for cosmetic procedures have been shown to have regenerative power due to their stem cell content. Our purpose was to compare the clinical changes in the treatment of radiation dermatitis in breast cancer patients with the application of fat graft versus traditional therapy with general measures.A randomized controlled clinical trial was performed, 22 patients were recruited and randomly assigned to one of two groups: an intervention group that received an autologous fat graft and a control group that received treatment with general measures; a 6-week follow-up was performed to determine the presence and classification of radiodermatitis using the LENT/SOMA scales, as well as biopsies. Women were included, with a diagnosis of breast cancer, Eastern Cooperative Oncology Group 0 or 1, attended in our hospital during September 2023 to October 2024, older than 18 years, undergoing lumpectomy or mastectomy and in radiotherapy as part of the treatment scheme for breast cancer.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Patients who received general care | No Intervention | Patients who received daily skin washing with warm water and mild soap (pH neutral, fragrance free) without scrubbing. | |
| Patients who received autologous fat filtration | Active Comparator | Patients who underwent a surgical procedure and autologous fat processing for subsequent fat filtration. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Autologous fat filtration | Procedure | Patients who underwent a surgical procedure and autologous fat processing for subsequent fat filtration. |
|
| Measure | Description | Time Frame |
|---|---|---|
| Number of patients with radiodermatitis | The number of patients with radiodermatitis secondary to radiotherapy will be measured from the day they received the treatment until six weeks later. | From the start to six week later |
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Inclusion Criteria:
Exclusion Criteria:
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Belisario Dominguez 1000 | Guadalajara | Jalisco | 44329 | Mexico |
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| ID | Term |
|---|---|
| D001943 | Breast Neoplasms |
| D011855 | Radiodermatitis |
| ID | Term |
|---|---|
| D009371 | Neoplasms by Site |
| D009369 | Neoplasms |
| D001941 | Breast Diseases |
| D012871 | Skin Diseases |
| D017437 | Skin and Connective Tissue Diseases |
| D003872 | Dermatitis |
| D011832 | Radiation Injuries |
| D014947 | Wounds and Injuries |
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