Receptive Music Interventions During Intradermal Testing in Children

Receptive Music Interventions During Intradermal Testing in Children: A Randomized Controlled Trial Comparing Solfeggio Frequencies and Turkish Classical Music on Pain and Parental Anxiety

The study summary and design were to assess procedural anxiety and stress in parents and pain perception in children during intradermal testing. Music medicine was incorporated into the study design as a nonpharmacological intervention. Two distinct auditory modalities were used: solfeggio frequencies-174 Hz, 285 Hz, 396 Hz, and 528 Hz-which have been suggested to interact with the human energy field through resonance-based mechanisms, and Turkish classical musical modes (makams), such as Rast, Hicaz, Uşşak, Neva, and Saba, which are modal systems that include microtonal intervals and follow specific melodic progressions that are often associated with different emotional and spiritual effects as well as sensory and emotional regulation potential.

Inclusion Criteria:

1. Children aged between 2 and 17 years
2. Referred to the Pediatric Allergy Clinic for evaluation of suspected drug hypersensitivity reactions
3. Accompanied by a parent or legal guardian willing to participate
4. Written informed consent obtained from parents or legal guardians

Exclusion Criteria:

1. Known neurological, psychiatric, or developmental disorders in the child
2. Use of sedatives or analgesic medications within 24 hours prior to testing
3. Hearing impairment or auditory processing disorders in the child4.Non-consent or withdrawal of consent by parent or guardian
4. Inability of the parent to complete anxiety assessments (e.g., due to language or cognitive barriers)