Treatment of Plane Warts With Topical and Oral Retinoids

Evaluation of Topical Tretinoin 0.05% Alone Versus Combination With Oral Isotretinoin (0.5 mg/kg/Day) in the Treatment of Plane Warts

The aim of this study was to compare the effectiveness and safety of topical tretinoin cream 0.05% alone against combination with oral isotretinoin (0.5 mg/kg/day) for treatment of plane warts.

This study included 39 patients divided into two groups. Treatment was given for three months duration. Patients were followed-up for further three months to assess the recurrence rate. Combination treatment led to a faster resolution and a higher percentage of complete response. It presents a promising effective alternative option for treatment of plane warts.

Inclusion Criteria:

• Patients above 12 years diagnosed with plane warts.
• Patients who had not received any treatment for warts in the last month.

Exclusion Criteria:

• Pregnancy and lactation.
• Abnormal lipid profile.
• Significant hepatic or renal dysfunction.
• Depression.