Combination Therapy for Warts: Candida Antigen vs. Topical Keratolytic

Comparative Efficacy of Topical Salicylic Acid/Lactic Acid, Intralesional Candida Antigen, and Their Combination in the Treatment of Warts: A Randomized, Assessor-Blinded, Controlled Trial

Objective: To compare the efficacy, safety, and recurrence rates of topical salicylic acid/lactic acid (SA/LA) monotherapy (Group A), intralesional Candida antigen (CA) monotherapy (Group B), and their combination (Group C) for the treatment of warts.

Inclusion Criteria:

1. Single or multiple warts.
2. Aged 5 to 60 years.
3. Eligible for both topical and intralesional treatments.
4. No prior wart treatment for at least 1 month.

Exclusion Criteria:

1. Pregnancy or lactation.
2. Immunosuppression or use of immunosuppressive drugs.
3. Known sensitivity to study ingredients.
4. Systemic/local inflammation or infection.
5. History of bleeding/clotting disorder, or use of anticoagulants/NSAIDs.
6. History of asthma, allergic skin disorders, or convulsions.
7. History of chronic systemic diseases (renal/hepatic failure, cardiovascular disorders).