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| ID | Type | Description | Link |
|---|---|---|---|
| 25/SS/0021 | Other Identifier | NHS Scotland A Research Ethics Committee |
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| Name | Class |
|---|---|
| NHS Grampian | OTHER_GOV |
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The goal of this study is to test if a new type of MRI scanner, called Field-Cycling Imaging (FCI), can show changes in the brain within the first day of a stroke due to a blocked blood vessel or bleeding in the brain. The main question it aims to answer is:
• Can FCI identify brain tissue that might recover within the first few hours after a stroke begins?
Participants will undergo a standard MRI scan and an FCI scan, as soon as possible after hospital admission.
Participants who have had a blocked blood vessel will also provide a blood sample and will have a follow up visit at 30 days for repeat of both scans and providing another blood sample.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Ischaemic stroke | Ischaemic stroke patients within 24 hours from symptom onset |
| |
| Haemorrhagic stroke | Patients with primary intracerebral haemorrhage within 24 hours from symptom onset |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| 3T MRI research scan | Other | Baseline MRI scan |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Agreement between extent of ischaemic stroke at-risk tissue/infarct core obtained from FCI dispersion maps and 3T MRI modalities at baseline | Receiver operator curves (ROC) curves comparing extent of at-risk tissue/infarct core obtained from FCI dispersion maps and from 3T MRI modalities at baseline at stroke onset. | Baseline at stroke onset |
| Measure | Description | Time Frame |
|---|---|---|
| Agreement between extent of haemorrhagic volume obtained from FCI dispersion maps and 3T MRI modalities at baseline | Receiver operator curves (ROC) curves comparing extent of haemorrhagic volume obtained from FCI dispersion maps and from 3T MRI modalities at baseline at stroke onset. | Baseline at stroke onset |
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Inclusion Criteria:
Exclusion Criteria:
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Participants with acute stroke admitted to Aberdeen Royal Infirmary.
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Mary Joan MacLeod, PhD | Contact | +44 1224 437842 | m.j.macleod@abdn.ac.uk | |
| Gordon D Waiter, PhD | Contact | +44 1224 438356 | g.waiter@abdn.ac.uk |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| University of Aberdeen | Recruiting | Aberdeen | AB25 2ZD | United Kingdom |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 39189899 | Background | Mallikourti V, Ross PJ, Maier O, Guzman-Gutierrez G, Franko E, Lurie DJ, Broche LM, Macleod MJ. Field-Cycling MRI for Identifying Minor Ischemic Stroke Below 0.2 T. Radiology. 2024 Aug;312(2):e232972. doi: 10.1148/radiol.232972. | |
| 39955477 | Background | Senn N, Ross PJ, Ayde R, Mallikourti V, Krishna A, James C, de Vries CF, Broche LM, Waiter GD, MacLeod MJ. Field-cycling imaging yields repeatable brain R1 dispersion measurement at fields strengths below 0.2 Tesla with optimal fitting routine. MAGMA. 2025 Jul;38(3):465-474. doi: 10.1007/s10334-025-01230-w. Epub 2025 Feb 15. |
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| Field-Cycling Imaging research scan |
| Other |
Baseline FCI scan |
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| Follow up 3T MRI research scan | Other | Day 30 3T MRI scan |
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| Follow up Field-Cycling Imaging research scan | Other | Day 30 FCI scan |
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| Blood samples for clotting experiments in vitro | Other | Thrombi from whole blood from ischaemic stroke patients will be formed and examined using bench top nuclear magnetic resonance (NMR) assays. At baseline and 30 days after stroke onset. |
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| Agreement of infarct core volume measurements obtained from FCI and 3T MRI at day 30 in ischaemic stroke patients |
Comparison of infarct core volumes on 30-day 3T FLAIR and baseline/30-day FCI T1 dispersion maps in ischaemic stroke patients. |
| 30 days after stroke onset |
| Agreement between T1 dispersion curve measurements obtained from in vivo clot in large intracerebral vessels and clot formed in vitro. | Extent of agreement between quantified T1 dispersion curve measurements obtained from in vivo imaging and benchtop Fast Field Cycling Nuclear Magnetic Resonance (FFC-NMR). Extent of correlation between thrombo-elastography measurements against in vivo measurements of T1 dispersion. | At baseline and 30 days after stroke onset |
| ID | Term |
|---|---|
| D020521 | Stroke |
| ID | Term |
|---|---|
| D002561 | Cerebrovascular Disorders |
| D001927 | Brain Diseases |
| D002493 | Central Nervous System Diseases |
| D009422 | Nervous System Diseases |
| D014652 | Vascular Diseases |
| D002318 | Cardiovascular Diseases |
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| ID | Term |
|---|---|
| D001800 | Blood Specimen Collection |
| D066298 | In Vitro Techniques |
| ID | Term |
|---|---|
| D013048 | Specimen Handling |
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D011677 | Punctures |
| D013514 | Surgical Procedures, Operative |
| D008919 | Investigative Techniques |
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