Pneumocystis in Patients Over 75 Year

Pneumocystis in Non-HIV Patients Over 75 Years Old: Epidemiological, Diagnostic, Microbiological and Therapeutic Characteristics

Pneumocystis pneumonia is an infectious disease caused by Pneumocystis jirovecii that affects the lung parenchyma preferentially. Historically described in an immunocompromised population through HIV.

Worldwide, the profile of patients affected by this pathology is changing due to two main factors:

• The sustainable stabilization of HIV patients.
• The emergence of new risk factors of immunosuppression. The geriatric population is particularly affected by these risk factors, increasing the incidence of pneumocystis in this population, which does not have HIV (solid cancer, hemopathy, immunosuppressive treatments, etc.).

There is currently no work specifically studying pneumocystis in this age group. The main objective of this study is to describe the clinical, biological and therapeutic data of a cohort of geriatric patients with pneumocystis, not carrying HIV, from January 1, 2010 to December 31, 2021, in all the centers surveyed.

Inclusion Criteria

1. Patient > or equal to 75 years of age

2. Microbiological diagnosis:

   • Direct examination with standard stain, finding trophozoite and/or P.jirovecii cyst (BAL or induced sputum) And/or
   • Direct examination with immunofluorescence, finding trophozoite and/or P.jirovecii cyst (BAL or induced sputum)
   • And/or
   • Positive PCR (BAL, sputum, nasopharyngeal swab or blood) and CT < 35

3. Absence of HIV infection

4. Hospitalization in French hospitals between 2010 and 2021

Non-inclusion criteria

1. Opposition of the patient to participate to the study