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The goal of this clinical trial is to investigate whether a three-day consumption of honey-sweetened black tea, green tea, and coffee will have an effect on blood pressure, heart rate, and blood glucose. The main questions it aims to answer are:
Does honey-sweetened black tea, green tea, and coffee, respectively, have the ability to influence blood pressure, heart rate, or blood glucose level?
Research will compare honey-sweetened black tea, green tea, and coffee to a placebo (warm water) to see if honey-sweetened black tea, green tea, and coffee work to reduce or increase blood pressure, heart rate, or blood glucose.
Participants will:
Take honey-sweetened black tea, green tea, and coffee, OR plain black tea, green tea, and coffee, OR warm water, one cup a day for 3 days The beverages will be taken at the Physiology laboratory, University of Uyo, and the participants will be observed for 60 minutes, during which their blood pressure, heart rate, and blood glucose level will be measured. This procedure will be repeated for the 3 days of study.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Control group | Placebo Comparator | Will receive 250 mL of warm water |
|
| Coffee group | Active Comparator | Will receive 2.25 g of coffee dissolved in 250 mL of hot water |
|
| Honey-sweetened coffee group | Active Comparator | Will receive 2.25 g of coffee plus 20 mL of honey put in 250 mL of hot water |
|
| Green tea group | Active Comparator | Will receive 2 g of green tea infuse in 250 mL of hot water |
|
| Honey-sweetened green tea group | Active Comparator | Will receive 2 g of green tea plus 250 mL of honey put in 250 mL of hot water |
|
| Black tea group | Active Comparator | Will receive 2 g of black tea infuse in 250 mL of hot water |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Warm water at 35 oC | Other | The placebo for the control group |
| |
| Measure | Description | Time Frame |
|---|---|---|
| Blood pressure | Will be measured before consumption of the beverages and at 15, 30, 45, and 60 minutes after consumption of the beverages. This procedure will be repeated for 3 consecutive days. | |
| Heart rate | Will be measured before consumption of the beverages and at 15, 30, 45, and 60 minutes after consumption of the beverages. This procedure will be repeated for 3 consecutive days. | |
| Blood glucose | Will be measured before consumption of the beverages and at 30 and 60 minutes after consumption of the beverages. This procedure will be repeated for 3 consecutive days. |
| Measure | Description | Time Frame |
|---|---|---|
| Age | Will obtained during the eligibility process | |
| Height | Will be measured on the first day of the experiment before the commencement of the experiment. | |
| Body weight |
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Inclusion Criteria:
Inclusion criteria are as follows:
Exclusion Criteria:
Exclusion criteria are as follows:
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| Name | Affiliation | Role |
|---|---|---|
| Esther O Aluko | University of Uyo | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Physiology laboratory, Physiology Department, Faculty of Basic Medical Sciences, University of Uyo | Uyo | Akwa Ibom State | 520003 | Nigeria |
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| Type | Includes Protocol | Includes SAP | Includes ICF | Document Label | Document Date | Document Uploaded Date | Document File Name |
|---|---|---|---|---|---|---|---|
| Prot_SAP_ICF | Yes | Yes | Yes | Study Protocol, Statistical Analysis Plan, and Informed Consent Form | May 23, 2025 |
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|
| Honey-sweetened black tea group | Active Comparator | Will receive 2 g of black tea plus 20 mL of honey put in 250 mL of hot water |
|
| Coffee |
| Other |
Instant coffee, Nescafé Gold Blend, manufactured by Nestlé Coffee Brand, Nestlé Global |
|
| Honey-sweetened coffee | Other | Instant coffee plus raw dark amber honey produced by Apis mellifera adansonii |
|
| Green tea | Other | Qualitea Natural Green Tea, packed by Qualitea Ceylon (PVT) LTD |
|
| Honey-sweetened green tea | Other | Green tea plus honey |
|
| Black tea | Other | Lipton Yellow Label Black Tea |
|
| Honey-sweetened black tea | Other | Black tea plus honey |
|
| Measurements will be taken over the course of the 3-day study prior to the commencement of the experiment each day. |
| May 23, 2025 |
| Prot_SAP_ICF_000.pdf |
| ID | Term |
|---|---|
| D003069 | Coffee |
| D013662 | Tea |
| ID | Term |
|---|---|
| D028321 | Plant Preparations |
| D001688 | Biological Products |
| D045424 | Complex Mixtures |
| D001628 | Beverages |
| D000066888 | Diet, Food, and Nutrition |
| D010829 | Physiological Phenomena |
| D019602 | Food and Beverages |
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