Gastrointestinal, pulmonary, nephrological, cardiac, neurologic and psychological effects in critically ill patients followed in the intensive care unit have been shown in the literature. However, the effects on ovarian reserve in these patients have not been sufficiently investigated and studies investigating this issue are limited in the literature. The synthesis, release frequency and amplitude of reproductive hormones change under stress. In addition, changes in ovarian homeostasis affect ovarian reserve. The aim of this study was to evaluate ovarian reserve in critically ill patients followed up in the intensive care unit.

Inclusion Criteria:

• 18-35 years of age
• Female patients followed in the intensive care unit for more than 24 hours for internal or surgical reasons,
• Women whose ovarian reserve is being evaluated,

Exclusion Criteria:

• Previous ovarian surgery, endometriosis, endometrioma,
• History of chemotherapy, radiotherapy,
• Ovarian cyst, malignancy and other ovarian pathologies,
• Women with single ovary,
• Women receiving hormone therapy,
• Polycystic ovary syndrome,
• Surgical intervention within the last 6 months,
• History of drug, alcohol, substance use,
• Women in pregnancy, puerperium, lactation,
• History of vaccination within the last 6 months

a group of healthy women without any disease and a group of patients hospitalized in intensive care unit.