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The study aimed to evaluate the cause and prognosis of hyperdynamic left ventricular ejection fraction in critically ill patients with sepsis.
Cardiovascular dysfunction is increasingly being recognized as a significant complication in sepsis, affecting patient outcomes.
Among the key parameters used to evaluate cardiac performance is the left ventricular ejection fraction (LVEF), typically assessed via transthoracic echocardiography (TTE).
LVEF has been extensively studied; most investigations into preserved ejection fraction tend to group all values ≥50% together, thereby overlooking the potential clinical implications of LVEF ≥70%, often referred to as hyperdynamic LVEF (HDLVEF).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Septic shock group | Patients underwent left ventricular ejection fraction (LVEF) assessment using two-dimensional echocardiography using visual estimation. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Transthoracic echocardiography | Device | Transthoracic echocardiography (TTE) was carried out. The assessment of left ventricular ejection fraction (LVEF) relied primarily on two-dimensional echocardiography using visual estimation. |
| Measure | Description | Time Frame |
|---|---|---|
| Intensive care unit mortality | Such patients are admitted to the intensive care unit (ICU), where a definitive diagnosis of sepsis is established using the Sequential Organ Failure Assessment (SOFA) score. This validated scoring system is widely recognized for its ability to predict mortality by evaluating dysfunction across six critical organ systems: respiratory, cardiovascular, hepatic, coagulation, renal, and neurological. The SOFA score is initially calculated upon ICU admission and is subsequently updated every 24 hours, using the most abnormal clinical or laboratory values recorded during the preceding day. | 28 days post-procedure |
| Measure | Description | Time Frame |
|---|---|---|
| Discharge against medical advice | Discharge against medical advice was recorded. | 28 days post-procedure |
| Incidence of patients who choose to leave the intensive care unit | Incidence of patients who choose to leave the intensive care unit against medical advice. |
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Inclusion Criteria:
Exclusion Criteria:
- Patients with previously documented abnormal transthoracic echocardiography (TTE) findings, such as severe valvular disease, poor echocardiographic windows, patients admitted to cardiothoracic intensive care unit (ICU), and those not meeting sepsis criteria.
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This prospective observational study involved 235 patients admitted to the Intensive Care Unit (ICU) from August 2022 to July 2023.
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Ain Shams University | Cairo | 11591 | Egypt |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 41319356 | Derived | Hedia DSM, Mahmoud HO, AbdelFattah AM, AbdelSalam EH, Mahmoud OS. Hyperdynamic left ventricular ejection fraction as a predictor of mortality in intensive care unit patients with septic shock. Heart Lung. 2026 Mar-Apr;76:106-112. doi: 10.1016/j.hrtlng.2025.11.015. Epub 2025 Nov 29. |
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The data will be available upon a reasonable request from the corresponding author after the end of study for one year.
After the end of study for one year.
The data will be available upon a reasonable request from the corresponding author.
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| 28 days post-procedure |
| ID | Term |
|---|---|
| D012772 | Shock, Septic |
| ID | Term |
|---|---|
| D018805 | Sepsis |
| D007239 | Infections |
| D018746 | Systemic Inflammatory Response Syndrome |
| D007249 | Inflammation |
| D010335 | Pathologic Processes |
| D013568 | Pathological Conditions, Signs and Symptoms |
| D012769 | Shock |
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| ID | Term |
|---|---|
| D004452 | Echocardiography |
| ID | Term |
|---|---|
| D057791 | Cardiac Imaging Techniques |
| D003952 | Diagnostic Imaging |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D014463 | Ultrasonography |
| D006334 | Heart Function Tests |
| D003935 | Diagnostic Techniques, Cardiovascular |
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