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The investigators propose to carry out a national retrospective study to collect epidemiological, biological, clinical and therapeutic data on microsporidiosis among heart transplant patients.
Microsporidia constitute a large family of intracellular eukaryotes infecting a wide range of hosts, ranging from insects to mammals and birds. Within this group, some species are responsible for intestinal syndromes manifested by abundant watery diarrhea, which can be particularly severe in immunocompromised individuals. In the 1980s, HIV-positive patients at the AIDS stage represented the primary population at risk. Nowadays, the most frequently affected patients among immunocompromised individuals are solid organ transplant recipients, for whom the management of this infection can be challenging. A neglected pathology until a few years ago, epidemiological data describing intestinal microsporidiosis in solid organ transplant recipients are scarce. The invesigators previously published the first data in kidney and liver transplant recipients. Here the investigators propose to carry out a national retrospective study to collect epidemiological, biological, clinical and therapeutic data on heart transplant patients.
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| Measure | Description | Time Frame |
|---|---|---|
| Demographic data: age | expressed in years old | 1 year |
| Demographic data: sex | choice between: male/female | 1 year |
| Time between transplant and microsporidiosis | expressed in days, or years if >365 days | 1 year |
| At diagnosis: number of days since the onset of symptoms | expressed in number of days | 1 year |
| Weight loss at diagnosis | expressed in kilogram or in percent (compared to usual weight of the patient) | 1 year |
| Dosage of immunosuppressants at diagnosis | 1 year | |
| Time to stool negativation | expressed in number of days between onset of treatment and first negative PCR during follow-up | 1 year |
| Creatinine level in blood at Day 0 (diagnosis) and Month 3 | expressed in µM | 3 months |
| Numeration of cells in blood: platelets, lymphocytes, neutrophils at Day 0 (diagnosis) and Month 3 |
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Inclusion Criteria:
Exclusion Criteria:
-patient opposition
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Heart transplant patients with microsporidiosis
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Lise Laclautre | Contact | +33473754963 | promo_interne_drci@chu-clermontferrand.fr |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| CHU Gabriel Montpied | Recruiting | Clermont-Ferrand | 63000 | France |
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| ID | Term |
|---|---|
| D016881 | Microsporidiosis |
| ID | Term |
|---|---|
| D009181 | Mycoses |
| D001423 | Bacterial Infections and Mycoses |
| D007239 | Infections |
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expressed in Giga per litre |
| 3 months |
| Gammaglobulins in blood at diagnosis | expressed in gram per litre | 1 year |