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ICU patients are recruited after at least 5 days treatment with continuous renal replacement therapy. Blood samples are drawn at time of recruitment and then every 3-5 days until ceseation of renal replacement therapy.
Samples will be analyzed for concentrations of trace elements, vitamins and amino acids.
10 adult ICU patients treated for two weeks without renal replacement therapy will be sampled at one time point to serve as controls.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| CRRT patients | Patients, all ages, that receive CRRT for at least five days. |
| |
| Non-CRRT patient | Adult patients, >17 yo, treated in the ICU for 10-15 days without renal replacement therapy |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| blood test | Diagnostic Test | Blood samples are drawn every 3-5 days in the RRT group but only once in the control group |
|
| Measure | Description | Time Frame |
|---|---|---|
| Concentration of trace element | Measurments of trace elements and vitamins as compared to established reference values as well as non-CRRT controls | From enrollment to the end of treatment at 4 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| Amino acids | Concentration of amino acids in plasma | From enrollment to the end of treatment at 4 weeks |
| Vitamins | Water soluble vitamins, concentration in plasma. Compared to non-crrt controls and established references |
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Inclusion Criteria CRRT group:
Exclusion Criteria:
Inclusion criteria non-CRRT group
- ICU care 10-15 days without any dialysis treatment
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Patient of all ages treated with CRRT
| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jonathan Grip, MD, PhD | Contact | +46 73 623 09 06 | jonathan.grip@regionstockholm.se | |
| Kristina Kilsand, Research nurse | Contact | +46 8 123 810 03 | kristina.kilsand@regionstockholm.se |
| Name | Affiliation | Role |
|---|---|---|
| Jonathan Grip, MD, PhD | Karolinska University Hospital | Principal Investigator |
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Data will be availible upon reasonable request but the small sample size number and specificity of medical conditions makes blinding to challenging for public release
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| ID | Term |
|---|---|
| D006403 | Hematologic Tests |
| ID | Term |
|---|---|
| D019411 | Clinical Laboratory Techniques |
| D019937 | Diagnostic Techniques and Procedures |
| D003933 | Diagnosis |
| D008919 | Investigative Techniques |
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Plasma is sampled and stored in -80 degress C before analysis
| At all measuring points |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |