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ICU patients treated with continuous renal replacement therapy is recruited prior to start of treatment.
Blood samples are drawn and then dialysis start without amino acid supplementation. After a few hours samples are drawn from blood and dialysate. Then patients are given amino acid supplementation (33.5g/24hrs) for 20-24 hours. New samples are drawn and amino acid supplementation is increased to 67g/24hrs and new samples are drawn after additional 24 hours. Then CRRT will continue with the full amino acid supplementation (standars of care).
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| All patients | Experimental | All patients will start CRRT treatment without amino acid supplementation After a few hours samples are drawn from blood and dialysate Patients then receive low dose of supplementation for 24 hours (33.5g, 250 ml Glavamin, Fresenius Kabi) and new samples are drawn After that patients receive full supplementation (67g, 500 ml Glavamin, Fresenius Kabi) for the rest the of CRRT treatment. After 24 hours of this treatment new samples are drawn. |
|
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| Amino acid supplementation (Glavamin, Fresenius Kabi) | Dietary Supplement | Mixture of amino acids (67 g / 500 ml) given intravenously |
|
| Measure | Description | Time Frame |
|---|---|---|
| Balance of amino acids | Total balance of amino acid losses and supplementation given | After 3 days of dialysis |
| Measure | Description | Time Frame |
|---|---|---|
| Amino acid concentration in plasma | Concentration of various amino acids in plasma without and with supplementation | After 3 days of dialysis |
| Concentration of vitamins and trace elements | Analysis of various trace elements and vitamins |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Jonathan Grip, MD, PhD | Contact | +46736230906 | jonathan.grip@regionstockholm.se |
| Name | Affiliation | Role |
|---|---|---|
| Jonathan Grip, MD, PhD | Karolinska University Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Karolinska University Hospital | Recruiting | Stockholm | 14186 | Sweden |
Data will be availible per request
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| ID | Term |
|---|---|
| D058186 | Acute Kidney Injury |
| ID | Term |
|---|---|
| D051437 | Renal Insufficiency |
| D007674 | Kidney Diseases |
| D014570 | Urologic Diseases |
| D052776 | Female Urogenital Diseases |
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| After 3 days of dialysis |
| D005261 |
| Female Urogenital Diseases and Pregnancy Complications |
| D000091642 | Urogenital Diseases |
| D052801 | Male Urogenital Diseases |