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the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients
the proposed study aims to investigate the effect of Quercetin in treatment of periodontitis patients not having systemic diseases.the 2ry aim of study to estimate the neacular factor kabba B level in gingival crevicular fluids.
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin | Experimental | selected patients receive SRP and chitosan nanoparticles gel loaded by quercetin |
|
| Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel. | Experimental | selected patients receive SRP and chitosan nanoparticles gel |
|
| Group 3: Periodontitis patients treated by NSPT only | Active Comparator | NSPT |
|
| Group 4: Periodontally healthy subjects. | No Intervention | healthy individual act as control group |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| NSP and chitosan nanoparticles gel loaded by quercetin | Drug | NSP and chitosan nanoparticles gel loaded by quercetin |
|
| Measure | Description | Time Frame |
|---|---|---|
| assessment clinical attachment level by UNC 15 periodontal probe | 12 weeks |
| Measure | Description | Time Frame |
|---|---|---|
| assessment of the gingival crevicular levels of NF-κB by Elisa kit | 12 weeks |
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Inclusion Criteria:
- Patients of both sexes with an age ranging between 25 and 55 years will be included in the study. Patients diagnosed as having periodontitis based on clinical and radiographic examinations will be included
Exclusion Criteria:
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| Name | Affiliation | Role |
|---|---|---|
| Jilan mohamed | Mansoura University | Study Director |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Faculty of Dentistry, Mansoura University | Aga | Egypt |
Clinical effect of Quercetin in treatment of periodiontal pocket
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Group 1: Periodontitis patients treated by NSPT and chitosan nanoparticles gel loaded by quercetin.
Group 2: Periodontitis patients treated by NSPT and chitosan nanoparticles gel. Group 3: Periodontitis patients treated by NSPT only. Group 4: Periodontally healthy subjects.
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| NSP and chitosan nanoparticles gel | Drug | NSP and chitosan nanoparticles gel |
|
| scaling and root planning | Procedure | NSPT |
|
| ID | Term |
|---|---|
| D010514 | Periodontal Pocket |
| ID | Term |
|---|---|
| D010518 | Periodontitis |
| D010510 | Periodontal Diseases |
| D009059 | Mouth Diseases |
| D009057 | Stomatognathic Diseases |
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| ID | Term |
|---|---|
| D014080 | Tooth Exfoliation |
| ID | Term |
|---|---|
| D009063 | Dental Physiological Phenomena |
| D055688 | Digestive System and Oral Physiological Phenomena |
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