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The investigator would like to investigate the impact of theta-burst stimulation over left DLPFC in autism with minimally verbal ability or intellectual disability
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| Active | Active Comparator | Participants received the real intervention of TBS (iTBS 1200) over the left dorsolateral prefrontal cortex for 4 weeks (5 days/week). *iTBS = intermittent theta burst stimulation |
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| Sham | Sham Comparator | Participants received the sham intervention of TBS (with sham coil) over the left dorsolateral prefrontal cortex for 4 weeks (5 days/week). |
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| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| intermittent theta burst stimulation | Device | stimulatory protocol |
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| Measure | Description | Time Frame |
|---|---|---|
| Total Scores of Aberrant Behavior Checklist | Aberrant Behavior Checklist is a parents' report questionnaire for aberrant behavior. The lower scores stand for less aberrant behavior. | Baseline, Week 4, Week 8 and Week 12 |
| Total Scores of Emotional Dysregulation Inventory | Emotional Dysregulation Inventory is a parents' report questionnaire for emotional dysregulation. The lower scores stand for better emotional regulation. | Baseline, Week 4, Week 8 and Week 12 |
| Total Scores of Child Behavior Checklist | Child Behavior Checklist is a parents' report questionnaire for behavioral and emotional problems. The lower scores stand for better behavioral and emotional regulation. | Baseline, Week 4, Week 8 and Week 12 |
| Measure | Description | Time Frame |
|---|---|---|
| Total Scores of Social Responsiveness Scale | Social Responsiveness Scale can measure the autism clinical severity. The lower scores stand for better social responsiveness. | Baseline, Week 4, Week 8 and Week 12 |
| Total Scores of Repetitive Behavior Scale-Revised |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Hsing-Chang Ni, Ph.D | Contact | 88633281200 | 2479 | alanni0918@yahoo.com.tw |
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| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Chang Gung Memorial Hospital | Taoyuan | Taiwan |
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Repetitive Behavior Scale-Revised is a questionnaire that focuses on repetitive behavior. The lower scores stand for lower repetitive behavior. |
| Baseline, Week 4, Week 8 and Week 12 |
| Total Scores of Adaptive Behavior Assessment System | Adaptive Behavior Assessment System is a parents' report questionnaire for adaptive behavior. The higher scores stand for better adaptive behavior. | Baseline, Week 4, Week 8 and Week 12 |
| Total Scores of Anxiety, Depression, and Mood Scale | Anxiety, Depression, and Mood Scale is a parents' report questionnaire for mental disorders (manic/ hyperactive behavior, depressed mood, social avoidance, general anxiety, obsessive/compulsive behavior) . The higher scores stand for higher mental problem. | Baseline, Week 4, Week 8 and Week 12 |
| Accuracy of Frith-Happe Animation | A quick and objective test of Theory of Mind. 8 questions in total, the more correct questions stand for better Social Cognition. | Baseline, Week 4, Week 8 and Week 12 |
| Accuracy of Eyes Task | An advanced test for Theory of Mind. 43 questions in total, the more correct questions stand for better social skills. | Baseline, Week 4, Week 8 and Week 12 |
| Accuracy of Wisconsin Card Sorting Test | An advanced test for cognitive flexibility. 128 questions in total, the more correct questions stand for better cognitive flexibility. | Baseline, Week 4, Week 8 and Week 12 |
| Accuracy of Raven's Progressive Matrices | An advanced test for for executive function. 60 questions in total, the more correct questions stand for better executive function. | Baseline, Week 4, Week 8 and Week 12 |
| Total Scores of Behavior Rating Inventory of Executive Function | Behavior Rating Inventory of Executive Function is a parents' report questionnaire for executive function. The lower scores stand for better executive function. | Baseline, Week 4, Week 8 and Week 12 |
| ID | Term |
|---|---|
| D000067877 | Autism Spectrum Disorder |
| D008607 | Intellectual Disability |
| ID | Term |
|---|---|
| D002659 | Child Development Disorders, Pervasive |
| D065886 | Neurodevelopmental Disorders |
| D001523 | Mental Disorders |
| D019954 | Neurobehavioral Manifestations |
| D009461 | Neurologic Manifestations |
| D009422 | Nervous System Diseases |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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