Therapeutic Impacts of Theta Burst Stimulation Over Bilateral Posterior Superior Temporal Sulcus in Autism Spectrum Disorder

Therapeutic Impacts of Theta Burst Stimulation Over Bilateral Posterior Superior Temporal Sulcus in Autism Spectrum Disorder: a Comprehensive Study Integrating Clinical Symptoms, Neuropsychological Function and MRI

The investigator would like to investigate the impact of intermittent theta burst stimulation over bilateral posterior superior temporal sulcus in autism spectrum disorder

Inclusion Criteria:

• Autism spectrum disorder, confirmed by Autism Diagnostic Observation Schedule II (CSS≧6)
• No change in psychiatric drugs within one month

Exclusion Criteria:

• Previous or current severe neurological disorder such as epilepsy, visual or hearing impairment
• Previous or current severe systemic disease such as cardiovascular disease, diabetes or infection
• Previous or current severe brain injury
• Implementation of metal materials such as pacemaker or medication pump
• Previous or current severe psychiatric disorders such as schizophrenia, bipolar disorder or substance abuse
• Pregnancy
• Individuals with a significant brain abnormality such as intracranial space occupied lesions
• History of brain surgery or nervous system infection, such as meningitis and encephalitis
• Previous febrile seizures
• Concurrent use of medications which increased the risk of seizure attack.
• Participate another clinical trial within one month.
• Unable to complete MRI scan (claustrophobia)
• Skin trauma on application site
• Individuals with a large ischemic scar
• Individuals suffering from multiple sclerosis
• Individuals suffering from sleep deprivation during rTMS procedures
• Individuals with a heavy consumption of alcohol
• Individuals with a migraine headache from increased intracranial pressure