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This study investigates the relationship between temperament traits and menopausal symptoms using the TEMPS-A and MRS scales in women at menopausal transition stages. It is a cross-sectional observational study.
This observational, cross-sectional study aims to investigate the relationship between temperament traits and menopausal symptoms in women in the menopausal transition stage, specifically classified as STRAW stages -1, +1a, and +1b. Participants are recruited from menopause outpatient clinics.
Data are collected through the administration of the validated Temperament Evaluation of Memphis, Pisa, Paris and San Diego Autoquestionnaire (TEMPS-A) and the Menopause Rating Scale (MRS).
Participants voluntarily complete the questionnaires after providing informed consent. All responses are anonymized and securely stored.
Quality assurance measures include verification of data entry, use of validated scales, and compliance with ethical standards approved by the Istanbul Medipol University Non-Interventional Clinical Research Ethics Committee.
No interventions are applied; the study strictly follows observational registry procedures.
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| Measure | Description | Time Frame |
|---|---|---|
| TEMPS-A Depressive Subscale Score at Baseline | Score from the depressive subscale of the TEMPS-A questionnaire, assessing baseline depressive temperament | Baseline (single time point at enrollment) |
| TEMPS-A Cyclothymic Subscale Score at Baseline | Score from the cyclothymic subscale of the TEMPS-A questionnaire, assessing mood instability. | Baseline (single time point at enrollment) |
| TEMPS-A Hyperthymic Subscale Score at Baseline | Score from the hyperthymic subscale of the TEMPS-A questionnaire, assessing elevated or overly positive mood tendencies. | Baseline (single time point at enrollment) |
| TEMPS-A Irritable Subscale Score at Baseline | Score from the irritable subscale of the TEMPS-A questionnaire, assessing baseline tendency toward irritability. | Baseline (single time point at enrollment) |
| TEMPS-A Anxious Subscale Score at Baseline | Score from the anxious subscale of the TEMPS-A questionnaire, assessing trait anxiety. | Baseline (single time point at enrollment) |
| MRS Somatic Subscale Score at Baseline | Somatic subscore of the MRS, measuring physical symptoms such as hot flashes and sleep problems. | Baseline (single time point at enrollment) |
| MRS Psychological Subscale Score at Baseline |
| Measure | Description | Time Frame |
|---|---|---|
| Correlation Between TEMPS-A Subscale Scores and MRS Total/Subscale Scores | The relationship between affective temperament traits (TEMPS-A: depressive, cyclothymic, hyperthymic, irritable, and anxious) and menopausal symptom severity (MRS total and subscale scores) will be assessed using Pearson or Spearman correlation coefficients. The analysis aims to determine whether specific temperament profiles are associated with increased symptom burden. |
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Inclusion Criteria:
Exclusion Criteria:
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Women in the menopausal transition stage, classified as STRAW stages -1, +1a, and +1b, attending menopause outpatient clinics.
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| Name | Affiliation | Role |
|---|---|---|
| Cemile Ilhan, MD | Bagcilar Training and Research Hospital | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| Bağcılar Training and Reserach Hospital | Istanbul | 34200 | Turkey (Türkiye) |
| PubMed Identifier | Type | Citation | Retractions |
|---|---|---|---|
| 42091421 | Derived | Hayirlioglu N, Ilhan C. Affective Temperament Traits as Predictors of Menopausal Symptom Severity in the Late Menopausal Transition and Early Postmenopause. J Obstet Gynaecol Res. 2026 May;52(5):e70317. doi: 10.1111/jog.70317. |
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Psychological subscore of the MRS, reflecting symptoms such as depressive mood, irritability, and anxiety.
| Baseline (single time point at enrollment) |
| MRS Urogenital Subscale Score at Baseline | Urogenital subscore of the MRS, assessing symptoms such as vaginal dryness or urinary complaints. | Baseline (single time point at enrollment) |
| MRS Total Score at Baseline | Total score from the Menopause Rating Scale (MRS), reflecting overall menopausal symptom severity. | Baseline (single time point at enrollment) |
| Baseline (single time point at enrollment) |