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| ID | Type | Description | Link |
|---|---|---|---|
| 5R01NS129059-03 | U.S. NIH Grant/Contract | View source |
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| Name | Class |
|---|---|
| National Institute of Neurological Disorders and Stroke (NINDS) | NIH |
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The purpose of this study is to assess thalamocortical (TC) connectivity during tonic pressure pain, to evaluate alpha activity during tonic pressure pain and to determine pressure pain ratings by using Electroencephalography (EEG), Functional Magnetic Resonance Imaging (fMRI), Transcranial Alternating Current Stimulation (tACS), sham and Transcranial random noise stimulation (tRNS)
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| Label | Type | Description | Intervention Names |
|---|---|---|---|
| tACS then tRNS then sham | Experimental |
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| tACS then sham then tRNS | Experimental |
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| tRNS then tACS then sham | Experimental |
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| tRNS then sham then tACS | Experimental |
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| Sham then tRNS then tACS | Experimental |
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| Sham then tACS then tRNS | Experimental |
| Name | Type | Description | Arm Group Labels | Other Names |
|---|---|---|---|---|
| transcranial alternating current stimulation (tACS) | Device | Participants will get a personalized brain stimulation: a 2 milliampere (mA) oscillating current that matches their natural alpha brain wave frequency (8-12 Hz), determined by a quick 3-minute EEG before the session. |
| Measure | Description | Time Frame |
|---|---|---|
| Change in thalamocortical (TC) connectivity during tonic pressure pain using fMRI | pre-stimulation, post-stimulation (about 30 minutes) | |
| Change in alpha activity during tonic pressure pain using EEG | pre-stimulation, post-stimulation (about 30 minutes) |
| Measure | Description | Time Frame |
|---|---|---|
| Change in pain as assessed by the Visual Analog Scale (VAS) | The VAS is scored from 0 = no pain; 10 = the most intense pain tolerable, higher number indicating more pain | pre-stimulation, post-stimulation (about 30 minutes) |
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Inclusion Criteria:
Exclusion Criteria:
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| Name | Role | Phone | Extension | |
|---|---|---|---|---|
| Wen Li, PhD | Contact | (713) 486-2700 | Wen.Li.1@uth.tmc.edu | |
| Jada Malveaux | Contact | (713) 486-2700 | Jada.Malveaux@uth.tmc.edu |
| Name | Affiliation | Role |
|---|---|---|
| Wen Li, PhD | The University of Texas Health Science Center, Houston | Principal Investigator |
| Facility | Status | City | State | ZIP | Country | Contacts |
|---|---|---|---|---|---|---|
| The University of Texas Health Science Center at Houston | Recruiting | Houston | Texas | 77030 | United States |
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| ID | Term |
|---|---|
| D010146 | Pain |
| ID | Term |
|---|---|
| D009461 | Neurologic Manifestations |
| D012816 | Signs and Symptoms |
| D013568 | Pathological Conditions, Signs and Symptoms |
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| ID | Term |
|---|---|
| D065908 | Transcranial Direct Current Stimulation |
| ID | Term |
|---|---|
| D004599 | Electric Stimulation Therapy |
| D013812 | Therapeutics |
| D003295 | Convulsive Therapy |
| D013000 | Psychiatric Somatic Therapies |
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| Sham | Device | Active sham stimulation with 60- second -tACS will be applied , then ramp down, and be reintroduced in the last 30 seconds to minimize awareness of the experimental condition |
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| transcranial random noise stimulation (tRNS) | Device | Participants will still get stimulation, but at random frequencies between 1 and 200 Hz (instead of targeted alpha waves). |
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| D004191 | Behavioral Disciplines and Activities |
| D004597 | Electroshock |
| D011580 | Psychological Techniques |